KIF24 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007019Biological processmicrotubule depolymerization
GO_0060271Biological processcilium assembly
GO_1902018Biological processnegative regulation of cilium assembly
GO_0007018Biological processmicrotubule-based movement
GO_0005814Cellular componentcentriole
GO_0005813Cellular componentcentrosome
GO_0032991Cellular componentprotein-containing complex
GO_0005829Cellular componentcytosol
GO_0005874Cellular componentmicrotubule
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding
GO_0003777Molecular functionmicrotubule motor activity
GO_0008017Molecular functionmicrotubule binding
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene nameKIF24
Protein nameKinesin family member 24
Kinesin-like protein KIF24
SynonymsC9orf48
DescriptionFUNCTION: Microtubule-dependent motor protein that acts as a negative regulator of ciliogenesis by mediating recruitment of CCP110 to mother centriole in cycling cells, leading to restrict nucleation of cilia at centrioles. Mediates depolymerization of microtubules of centriolar origin, possibly to suppress aberrant cilia formation . Following activation by NEK2 involved in disassembly of primary cilium during G2/M phase but does not disassemble fully formed ciliary axonemes. As cilium assembly and disassembly is proposed to coexist in a dynamic equilibrium may suppress nascent cilium assembly and, potentially, ciliar re-assembly in cells that have already disassembled their cilia ensuring the completion of cilium removal in the later stages of the cell cycle . Plays an important role in recruiting MPHOSPH9, a negative regulator of cilia formation to the distal end of mother centriole . .

AccessionsQ5T7B8
ENST00000684219.1
A0A804HHR8
ENST00000402558.7 [Q5T7B8-1]
ENST00000379174.7 [Q5T7B8-2]