I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| erythrocyte | 4 studies | 47% ± 8% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| erythrocyte | 4 studies | 47% ± 8% |
Insufficient scRNA-seq data for expression of KEL at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 97% | 190.52 | 2567 / 2642 | 30% | 0.54 | 211 / 705 |
| lung | 84% | 98.20 | 486 / 578 | 18% | 1.07 | 208 / 1155 |
| thymus | 86% | 62.04 | 562 / 653 | 14% | 0.63 | 85 / 605 |
| spleen | 100% | 765.32 | 241 / 241 | 0% | 0 | 0 / 0 |
| uterus | 68% | 63.35 | 116 / 170 | 30% | 2.28 | 139 / 459 |
| lymph node | 0% | 0 | 0 / 0 | 97% | 10.20 | 28 / 29 |
| peripheral blood | 94% | 441.81 | 873 / 929 | 0% | 0 | 0 / 0 |
| kidney | 87% | 93.43 | 77 / 89 | 4% | 0.32 | 37 / 901 |
| breast | 60% | 58.47 | 277 / 459 | 29% | 0.84 | 329 / 1118 |
| pancreas | 52% | 27.48 | 171 / 328 | 23% | 0.84 | 41 / 178 |
| ovary | 57% | 24.87 | 103 / 180 | 17% | 0.45 | 74 / 430 |
| esophagus | 57% | 53.89 | 825 / 1445 | 17% | 1.22 | 31 / 183 |
| skin | 27% | 11.61 | 488 / 1809 | 44% | 1.97 | 207 / 472 |
| prostate | 59% | 44.31 | 145 / 245 | 8% | 0.19 | 39 / 502 |
| tonsil | 0% | 0 | 0 / 0 | 58% | 9.73 | 26 / 45 |
| heart | 42% | 23.45 | 365 / 861 | 0% | 0 | 0 / 0 |
| intestine | 35% | 44.36 | 336 / 966 | 6% | 0.16 | 34 / 527 |
| liver | 25% | 16.40 | 57 / 226 | 16% | 3.57 | 63 / 406 |
| adipose | 40% | 19.91 | 485 / 1204 | 0% | 0 | 0 / 0 |
| bladder | 19% | 6.90 | 4 / 21 | 18% | 0.92 | 91 / 504 |
| muscle | 25% | 13.47 | 201 / 803 | 0% | 0 | 0 / 0 |
| blood vessel | 18% | 8.99 | 238 / 1335 | 0% | 0 | 0 / 0 |
| stomach | 8% | 3.58 | 28 / 359 | 10% | 0.38 | 28 / 286 |
| adrenal gland | 5% | 1.99 | 13 / 258 | 2% | 0.05 | 5 / 230 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0042552 | Biological process | myelination |
| GO_1901380 | Biological process | negative regulation of potassium ion transmembrane transport |
| GO_0048741 | Biological process | skeletal muscle fiber development |
| GO_0016485 | Biological process | protein processing |
| GO_0010961 | Biological process | intracellular magnesium ion homeostasis |
| GO_0006874 | Biological process | intracellular calcium ion homeostasis |
| GO_0051649 | Biological process | establishment of localization in cell |
| GO_0071805 | Biological process | potassium ion transmembrane transport |
| GO_0031133 | Biological process | regulation of axon diameter |
| GO_0008361 | Biological process | regulation of cell size |
| GO_0042310 | Biological process | vasoconstriction |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0016020 | Cellular component | membrane |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005794 | Cellular component | Golgi apparatus |
| GO_0005829 | Cellular component | cytosol |
| GO_0046872 | Molecular function | metal ion binding |
| GO_0004222 | Molecular function | metalloendopeptidase activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | KEL |
| Protein name | Blood group kell-cellano system Kell blood group glycoprotein (Kell metallo-endopeptidase (Kell blood group)) Kell blood group Kell blood group glycoprotein (EC 3.4.24.-) (CD antigen CD238) Kell blood group protein Kell blood group antigen (Kell blood group, metallo-endopeptidase) Truncated Kell blood group glycoprotein Kell blood group antigen, K null Kell immunogen Kell blood group antigen Cellano Kell blood group metallo-endopeptidase Kell blood group, metallo-endopeptidase Kell blood group antigen Kell protein Truncated Kell blood group antigen Truncated Kell blood group protein Kell blood group antigen, weak k Kell metallo-endopeptidase (Kell blood group) Kell blood group antigen variant KUCI Kell glycoprotein Truncated kell blood group antigen Cellano Kell blood group glycoprotein Kell |
| Synonyms | |
| Description | FUNCTION: Zinc endopeptidase with endothelin-3-converting enzyme activity. Cleaves EDN1, EDN2 and EDN3, with a marked preference for EDN3. . |
| Accessions | U3R8L4 A0A9E8M4C4 ENST00000467543.6 A0A9E8M4K4 A0A9E8M462 ENST00000631527.1 Q0KH89 A3F6J9 A0A077QP03 A0A9E8M4M4 Q09GN6 D8MJ82 ENST00000632261.1 Q2A682 P23276 A3F6K0 W5XNU5 Q2A681 Q05GI3 ENST00000476829.5 S6FW08 Q0KH85 X5FSQ3 ENST00000633704.1 Q0KH90 U4PCV3 A0A9E8S316 Q2A680 A0A9E8M5I9 A0A1W6BTL9 A8YPS5 A0A6B9JD81 E7ETW3 Q0KH93 A0A3G2M2G2 G8FSZ0 Q0KH86 W5XNU6 G8FPZ4 H0Y8A1 A0A6B9JF66 Q0KH95 A0A8D5UND5 A0A9E8M4A0 A0A9E8S179 W5XPK6 Q0KH97 ENST00000460479.2 A0A9E8M4N1 A0A0A1TE50 Q0KH87 A0A8D9FW36 U5XGV3 Q16297 Q0KH88 A0A077QPI2 Q0KH91 Q0KH84 ENST00000355265.7 A0A2D1QUX2 A0A9E8M480 A0A386AST0 G8FSY9 A0A9E8M476 A0A9E8M481 A0A2D1QUX7 A0A9E8S0H9 ENST00000615381.2 B5U6Z5 Q0KH83 G0TQY7 W5XPJ0 A0A0J9YXC0 E9PHG0 A0A9E8RZK3 W5XWM4 C7TP28 A0A9E8S111 Q06AK5 A0A1W6BTM7 Q0KH92 A0A6B9KRX0 G8FSY8 A0A9E8M5U7 U5XI03 A0A0J9YXV8 A0A7S9FT42 A3F6J8 A0A1W6BTL0 |
