KCTD6 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051260Biological processprotein homooligomerization
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0016567Biological processprotein ubiquitination
GO_0045879Biological processnegative regulation of smoothened signaling pathway
GO_0031430Cellular componentM band
GO_0005829Cellular componentcytosol
GO_0030506Molecular functionankyrin binding
GO_0042802Molecular functionidentical protein binding
GO_0097602Molecular functioncullin family protein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameKCTD6
Protein nameBTB/POZ domain-containing protein KCTD6 (KCASH3 protein) (Potassium channel tetramerization domain-containing protein 6)
Potassium channel tetramerization domain containing 6
Synonyms
DescriptionFUNCTION: Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1; the function seems to depend on KCTD11:KCTD6 oligomerization. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1; the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB) . Involved in regulating protein levels of ANK1 isoform Mu17 probably implicating CUL3-dependent proteasomal degradation . .

AccessionsENST00000355076.6
ENST00000490264.1
A0A1D5RMQ6
F5H7I0
ENST00000491093.5
ENST00000404589.8
Q8NC69
ENST00000479179.1