KCTD21 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of KCTD21 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of KCTD21 at tissue level.

III. Associated gene sets

GO_0051260Biological processprotein homooligomerization
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0016567Biological processprotein ubiquitination
GO_0045879Biological processnegative regulation of smoothened signaling pathway
GO_0042802Molecular functionidentical protein binding
GO_0097602Molecular functioncullin family protein binding
GO_0005515Molecular functionprotein binding
GO_0042826Molecular functionhistone deacetylase binding

IV. Literature review

[source]
Gene nameKCTD21
Protein namePotassium channel tetramerization domain containing 21
BTB/POZ domain-containing protein KCTD21 (KCASH2 protein) (Potassium channel tetramerization domain-containing protein 21)
Synonyms
DescriptionFUNCTION: Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1; the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB) . .

AccessionsENST00000529350.1
ENST00000528776.1
E9PRT1
E9PMS5
E9PM10
ENST00000525447.1
E9PK99
ENST00000526208.5
ENST00000530018.5
Q4G0X4
ENST00000340067.4
E9PJJ5