KCTD13 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0035024Biological processnegative regulation of Rho protein signal transduction
GO_0043149Biological processstress fiber assembly
GO_0051260Biological processprotein homooligomerization
GO_0016567Biological processprotein ubiquitination
GO_0050806Biological processpositive regulation of synaptic transmission
GO_0061351Biological processneural precursor cell proliferation
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0016477Biological processcell migration
GO_0016604Cellular componentnuclear body
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0031463Cellular componentCul3-RING ubiquitin ligase complex
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding
GO_0031267Molecular functionsmall GTPase binding

IV. Literature review

[source]
Gene nameKCTD13
Protein namePotassium channel tetramerization domain containing 13
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1 (hBACURD1) (BTB/POZ domain-containing protein KCTD13) (Polymerase delta-interacting protein 1) (TNFAIP1-like protein)
SynonymsPDIP1
BACURD1
PP6832
FKSG86
POLDIP1
DescriptionFUNCTION: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for synaptic transmission . The BCR(KCTD13) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome Degradation of RHOA regulates the actin cytoskeleton and promotes synaptic transmission (By similarity). .

AccessionsENST00000567795.3
I3L108
ENST00000566413.1
ENST00000568995.1
ENST00000648037.1
A0A3B3IS35
Q8WZ19
ENST00000649581.1
ENST00000561540.2
ENST00000568000.6
ENST00000308768.9
ENST00000566842.5
A0A3B3IS45
H3BM90
I3L3K4
I3L1U2