KCNU1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of KCNU1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of KCNU1 at tissue level.

III. Associated gene sets

GO_0022414Biological processreproductive process
GO_0071805Biological processpotassium ion transmembrane transport
GO_0034702Cellular componentmonoatomic ion channel complex
GO_0036126Cellular componentsperm flagellum
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0005267Molecular functionpotassium channel activity
GO_0060072Molecular functionlarge conductance calcium-activated potassium channel activity

IV. Literature review

[source]
Gene nameKCNU1
Protein namePotassium calcium-activated channel subfamily U member 1
Potassium channel subfamily U member 1 (Calcium-activated potassium channel subunit alpha-3) (Calcium-activated potassium channel, subfamily M subunit alpha-3) (KCa5) (Slowpoke homolog 3)
SynonymsKCNMA3
KCNMC1
SLO3
DescriptionFUNCTION: Testis-specific potassium channel activated by both intracellular pH and membrane voltage that mediates export of K(+). May represent the primary spermatozoan K(+) current. In contrast to KCNMA1/SLO1, it is not activated by Ca(2+) or Mg(2+). Critical for fertility. May play an important role in sperm osmoregulation required for the acquisition of normal morphology and motility when faced with osmotic challenges, such as those experienced after mixing with seminal fluid and entry into the vagina. .

AccessionsENST00000522417.1
A8MYU2
ENST00000522372.5
E5RHP1
ENST00000523973.5
E5RGP7
ENST00000399881.8
E5RJA6