I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| brush cell | 3 studies | 26% ± 8% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brush cell | 3 studies | 26% ± 8% |
Insufficient scRNA-seq data for expression of KCNQ4 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| prostate | 95% | 951.66 | 232 / 245 | 91% | 2.80 | 459 / 502 |
| intestine | 96% | 2180.11 | 923 / 966 | 72% | 2.88 | 377 / 527 |
| esophagus | 95% | 1910.13 | 1366 / 1445 | 72% | 3.63 | 131 / 183 |
| brain | 83% | 631.22 | 2186 / 2642 | 80% | 2.96 | 563 / 705 |
| stomach | 84% | 716.27 | 303 / 359 | 70% | 2.91 | 201 / 286 |
| uterus | 97% | 1513.29 | 165 / 170 | 53% | 5.23 | 241 / 459 |
| bladder | 90% | 1388.71 | 19 / 21 | 45% | 1.45 | 225 / 504 |
| ovary | 46% | 205.80 | 83 / 180 | 88% | 5.00 | 378 / 430 |
| breast | 85% | 396.70 | 388 / 459 | 47% | 2.29 | 525 / 1118 |
| lung | 77% | 289.65 | 446 / 578 | 54% | 1.89 | 622 / 1155 |
| pancreas | 47% | 177.78 | 155 / 328 | 81% | 3.56 | 145 / 178 |
| eye | 0% | 0 | 0 / 0 | 100% | 8.67 | 80 / 80 |
| ureter | 0% | 0 | 0 / 0 | 100% | 1.37 | 1 / 1 |
| blood vessel | 100% | 1733.99 | 1333 / 1335 | 0% | 0 | 0 / 0 |
| muscle | 99% | 894.90 | 791 / 803 | 0% | 0 | 0 / 0 |
| skin | 51% | 219.03 | 924 / 1809 | 42% | 1.71 | 196 / 472 |
| adipose | 81% | 393.57 | 973 / 1204 | 0% | 0 | 0 / 0 |
| heart | 60% | 235.56 | 518 / 861 | 0% | 0 | 0 / 0 |
| thymus | 23% | 72.51 | 149 / 653 | 12% | 0.59 | 71 / 605 |
| kidney | 6% | 19.12 | 5 / 89 | 23% | 0.74 | 211 / 901 |
| adrenal gland | 2% | 4.64 | 5 / 258 | 26% | 0.91 | 59 / 230 |
| tonsil | 0% | 0 | 0 / 0 | 27% | 0.52 | 12 / 45 |
| liver | 1% | 2.18 | 2 / 226 | 14% | 0.45 | 58 / 406 |
| peripheral blood | 4% | 11.90 | 36 / 929 | 0% | 0 | 0 / 0 |
| spleen | 1% | 3.01 | 3 / 241 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0042472 | Biological process | inner ear morphogenesis |
| GO_0007605 | Biological process | sensory perception of sound |
| GO_0006813 | Biological process | potassium ion transport |
| GO_0071805 | Biological process | potassium ion transmembrane transport |
| GO_0009925 | Cellular component | basal plasma membrane |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0008076 | Cellular component | voltage-gated potassium channel complex |
| GO_0005267 | Molecular function | potassium channel activity |
| GO_0005249 | Molecular function | voltage-gated potassium channel activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | KCNQ4 |
| Protein name | Potassium voltage-gated channel subfamily Q member 4 Potassium voltage-gated channel subfamily KQT member 4 (KQT-like 4) (Potassium channel subunit alpha KvLQT4) (Voltage-gated potassium channel subunit Kv7.4) |
| Synonyms | |
| Description | FUNCTION: Probably important in the regulation of neuronal excitability. May underlie a potassium current involved in regulating the excitability of sensory cells of the cochlea. KCNQ4 channels are blocked by linopirdin, XE991 and bepridil, whereas clofilium is without significant effect. Muscarinic agonist oxotremorine-M strongly suppress KCNQ4 current in CHO cells in which cloned KCNQ4 channels were coexpressed with M1 muscarinic receptors. |
| Accessions | P56696 H0Y6N7 ENST00000443478.3 ENST00000509682.6 [P56696-2] ENST00000347132.10 [P56696-1] |
