I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| mucus secreting cell | 3 studies | 37% ± 3% | |
| epithelial cell | 3 studies | 22% ± 6% | |
| transit amplifying cell | 3 studies | 33% ± 17% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| mucus secreting cell | 3 studies | 37% ± 3% | |
| epithelial cell | 3 studies | 22% ± 6% | |
| transit amplifying cell | 3 studies | 33% ± 17% |
Insufficient scRNA-seq data for expression of KCNN4 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| intestine | 80% | 1423.64 | 770 / 966 | 91% | 88.71 | 479 / 527 |
| prostate | 96% | 2763.47 | 235 / 245 | 74% | 83.92 | 372 / 502 |
| bladder | 81% | 1731.43 | 17 / 21 | 86% | 81.20 | 432 / 504 |
| stomach | 79% | 1050.73 | 285 / 359 | 78% | 59.67 | 224 / 286 |
| lung | 97% | 695.50 | 558 / 578 | 59% | 35.29 | 678 / 1155 |
| skin | 74% | 1861.15 | 1330 / 1809 | 72% | 88.88 | 339 / 472 |
| breast | 74% | 1377.70 | 338 / 459 | 54% | 28.41 | 600 / 1118 |
| esophagus | 53% | 271.83 | 759 / 1445 | 54% | 23.97 | 98 / 183 |
| spleen | 100% | 1902.34 | 241 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 57.36 | 1 / 1 |
| peripheral blood | 97% | 1541.86 | 904 / 929 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 97% | 101.36 | 28 / 29 |
| pancreas | 5% | 17.03 | 18 / 328 | 90% | 109.13 | 160 / 178 |
| thymus | 23% | 150.61 | 148 / 653 | 70% | 44.92 | 422 / 605 |
| uterus | 25% | 144.94 | 43 / 170 | 60% | 41.67 | 275 / 459 |
| blood vessel | 57% | 296.72 | 767 / 1335 | 0% | 0 | 0 / 0 |
| adipose | 51% | 241.93 | 617 / 1204 | 0% | 0 | 0 / 0 |
| ovary | 4% | 11.67 | 8 / 180 | 38% | 10.62 | 165 / 430 |
| tonsil | 0% | 0 | 0 / 0 | 40% | 16.66 | 18 / 45 |
| brain | 23% | 96.51 | 615 / 2642 | 5% | 1.34 | 34 / 705 |
| kidney | 16% | 68.39 | 14 / 89 | 3% | 1.38 | 26 / 901 |
| eye | 0% | 0 | 0 / 0 | 9% | 2.82 | 7 / 80 |
| adrenal gland | 3% | 11.57 | 7 / 258 | 2% | 1.26 | 5 / 230 |
| heart | 4% | 12.02 | 32 / 861 | 0% | 0 | 0 / 0 |
| liver | 1% | 3.08 | 3 / 226 | 2% | 1.46 | 8 / 406 |
| muscle | 0% | 2.05 | 4 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_1901381 | Biological process | positive regulation of potassium ion transmembrane transport |
| GO_0030322 | Biological process | stabilization of membrane potential |
| GO_0002376 | Biological process | immune system process |
| GO_0050862 | Biological process | positive regulation of T cell receptor signaling pathway |
| GO_0006813 | Biological process | potassium ion transport |
| GO_0046541 | Biological process | saliva secretion |
| GO_0006884 | Biological process | cell volume homeostasis |
| GO_0051649 | Biological process | establishment of localization in cell |
| GO_0071805 | Biological process | potassium ion transmembrane transport |
| GO_0050714 | Biological process | positive regulation of protein secretion |
| GO_0045332 | Biological process | phospholipid translocation |
| GO_0006816 | Biological process | calcium ion transport |
| GO_0006952 | Biological process | defense response |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0043025 | Cellular component | neuronal cell body |
| GO_0043005 | Cellular component | neuron projection |
| GO_0005829 | Cellular component | cytosol |
| GO_0031982 | Cellular component | vesicle |
| GO_0008076 | Cellular component | voltage-gated potassium channel complex |
| GO_0019903 | Molecular function | protein phosphatase binding |
| GO_0015269 | Molecular function | calcium-activated potassium channel activity |
| GO_0016286 | Molecular function | small conductance calcium-activated potassium channel activity |
| GO_0005267 | Molecular function | potassium channel activity |
| GO_0005516 | Molecular function | calmodulin binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0022894 | Molecular function | intermediate conductance calcium-activated potassium channel activity |
| Gene name | KCNN4 |
| Protein name | Small conductance calcium activated potassium channel type 4 transcript variant 2 Potassium calcium-activated channel subfamily N member 4 Intermediate-conductance Ca2+-activated K+ channel, KCa3.1 Small conductance potassium channel type4 transcript variant 4 Small conductance potassium channel type4 transcript variant 3 Intermediate conductance calcium-activated potassium channel protein 4 (SK4) (SKCa 4) (SKCa4) (IKCa1) (IK1) (KCa3.1) (KCa4) (Putative Gardos channel) |
| Synonyms | KCA4 IK1 IKCA1 SK4 |
| Description | FUNCTION: Forms a voltage-independent potassium channel that is activated by intracellular calcium . Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells . Plays a role in the late stages of EGF-induced macropinocytosis . . |
| Accessions | M0R1J0 ENST00000648319.1 D1MQ08 A0A7R6V2A8 D1MQ09 ENST00000598836.1 M0R2E8 ENST00000600408.1 ENST00000599720.5 ENST00000600909.1 M0R2F1 D1MQ10 O15554 A0A7R6V286 M0QZ70 A0A7R6V2A9 |
