KCNJ6 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0034765Biological processregulation of monoatomic ion transmembrane transport
GO_0006813Biological processpotassium ion transport
GO_1990573Biological processpotassium ion import across plasma membrane
GO_0005794Cellular componentGolgi apparatus
GO_0005886Cellular componentplasma membrane
GO_0008076Cellular componentvoltage-gated potassium channel complex
GO_0015467Molecular functionG-protein activated inward rectifier potassium channel activity
GO_0005515Molecular functionprotein binding
GO_0005242Molecular functioninward rectifier potassium channel activity

IV. Literature review

[source]
Gene nameKCNJ6
Protein nameG protein-activated inward rectifier potassium channel 2 (GIRK-2) (BIR1) (Inward rectifier K(+) channel Kir3.2) (KATP-2) (Potassium channel, inwardly rectifying subfamily J member 6)
SynonymsGIRK2
KCNJ7
KATP2
DescriptionFUNCTION: This potassium channel may be involved in the regulation of insulin secretion by glucose and/or neurotransmitters acting through G-protein-coupled receptors. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.

AccessionsENST00000645093.1
P48051
ENST00000609713.2