KCNJ4 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of KCNJ4 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of KCNJ4 at tissue level.

III. Associated gene sets

GO_0034765Biological processregulation of monoatomic ion transmembrane transport
GO_0006813Biological processpotassium ion transport
GO_1990573Biological processpotassium ion import across plasma membrane
GO_0045211Cellular componentpostsynaptic membrane
GO_0008076Cellular componentvoltage-gated potassium channel complex
GO_0005886Cellular componentplasma membrane
GO_0030659Cellular componentcytoplasmic vesicle membrane
GO_0016323Cellular componentbasolateral plasma membrane
GO_0030165Molecular functionPDZ domain binding
GO_0005515Molecular functionprotein binding
GO_0005242Molecular functioninward rectifier potassium channel activity

IV. Literature review

[source]
Gene nameKCNJ4
Protein nameKCNJ4 protein
Inward rectifier potassium channel 4 (HIRK2) (HRK1) (Hippocampal inward rectifier) (HIR) (Inward rectifier K(+) channel Kir2.3) (IRK-3) (Potassium channel, inwardly rectifying subfamily J member 4)
SynonymsIRK3
DescriptionFUNCTION: Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium (By similarity). .

AccessionsQ58F07
P48050
ENST00000303592.3