KCNE5 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of KCNE5 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of KCNE5 at tissue level.

III. Associated gene sets

GO_1901381Biological processpositive regulation of potassium ion transmembrane transport
GO_0060372Biological processregulation of atrial cardiac muscle cell membrane repolarization
GO_0060307Biological processregulation of ventricular cardiac muscle cell membrane repolarization
GO_1901379Biological processregulation of potassium ion transmembrane transport
GO_1903765Biological processnegative regulation of potassium ion export across plasma membrane
GO_1901380Biological processnegative regulation of potassium ion transmembrane transport
GO_0086011Biological processmembrane repolarization during action potential
GO_0086005Biological processventricular cardiac muscle cell action potential
GO_0098915Biological processmembrane repolarization during ventricular cardiac muscle cell action potential
GO_0086014Biological processatrial cardiac muscle cell action potential
GO_0060048Biological processcardiac muscle contraction
GO_0060306Biological processregulation of membrane repolarization
GO_1902260Biological processnegative regulation of delayed rectifier potassium channel activity
GO_0097623Biological processpotassium ion export across plasma membrane
GO_0086091Biological processregulation of heart rate by cardiac conduction
GO_0008016Biological processregulation of heart contraction
GO_2001257Biological processregulation of cation channel activity
GO_0005886Cellular componentplasma membrane
GO_0008076Cellular componentvoltage-gated potassium channel complex
GO_0005249Molecular functionvoltage-gated potassium channel activity
GO_0005251Molecular functiondelayed rectifier potassium channel activity
GO_1902282Molecular functionvoltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
GO_0086008Molecular functionvoltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
GO_0015459Molecular functionpotassium channel regulator activity
GO_0044325Molecular functiontransmembrane transporter binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameKCNE5
Protein nameCardiac voltage-gated potassium channel accessory subunit 5
Potassium voltage-gated channel subfamily E regulatory beta subunit 5 (AMME syndrome candidate gene 2 protein) (Potassium channel subunit beta MiRP4) (Potassium voltage-gated channel subfamily E member 1-like protein)
SynonymsAMMECR2
KCNE1L
DescriptionFUNCTION: Potassium channel ancillary subunit that is essential for generation of some native K(+) currents by virtue of formation of heteromeric ion channel complex with voltage-gated potassium (Kv) channel pore-forming alpha subunits. Functions as an inhibitory beta-subunit of the repolarizing cardiac potassium ion channel KCNQ1. .

AccessionsQ9UJ90
ENST00000372101.3
Q2N1H9