KCNE2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of KCNE2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of KCNE2 at tissue level.

III. Associated gene sets

GO_0060307Biological processregulation of ventricular cardiac muscle cell membrane repolarization
GO_1902259Biological processregulation of delayed rectifier potassium channel activity
GO_0071466Biological processcellular response to xenobiotic stimulus
GO_1901800Biological processpositive regulation of proteasomal protein catabolic process
GO_1901379Biological processregulation of potassium ion transmembrane transport
GO_0086002Biological processcardiac muscle cell action potential involved in contraction
GO_0086011Biological processmembrane repolarization during action potential
GO_0086005Biological processventricular cardiac muscle cell action potential
GO_0098915Biological processmembrane repolarization during ventricular cardiac muscle cell action potential
GO_0043586Biological processtongue development
GO_1901979Biological processregulation of inward rectifier potassium channel activity
GO_0071805Biological processpotassium ion transmembrane transport
GO_0060306Biological processregulation of membrane repolarization
GO_1902260Biological processnegative regulation of delayed rectifier potassium channel activity
GO_0097623Biological processpotassium ion export across plasma membrane
GO_0086091Biological processregulation of heart rate by cardiac conduction
GO_0086009Biological processmembrane repolarization
GO_1990573Biological processpotassium ion import across plasma membrane
GO_0016324Cellular componentapical plasma membrane
GO_0005886Cellular componentplasma membrane
GO_0005764Cellular componentlysosome
GO_0009986Cellular componentcell surface
GO_0008076Cellular componentvoltage-gated potassium channel complex
GO_0005251Molecular functiondelayed rectifier potassium channel activity
GO_1902282Molecular functionvoltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
GO_0042802Molecular functionidentical protein binding
GO_0015459Molecular functionpotassium channel regulator activity
GO_0005242Molecular functioninward rectifier potassium channel activity
GO_0044325Molecular functiontransmembrane transporter binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameKCNE2
Protein namePotassium voltage-gated channel subfamily E member 2 (MinK-related peptide 1) (Minimum potassium ion channel-related peptide 1) (Potassium channel subunit beta MiRP1)
Synonyms
DescriptionFUNCTION: Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. Associated with KCNH2/HERG is proposed to form the rapidly activating component of the delayed rectifying potassium current in heart (IKr). May associate with KCNQ2 and/or KCNQ3 and modulate the native M-type current. May associate with HCN1 and HCN2 and increase potassium current. Interacts with KCNQ1; forms a heterooligomer complex leading to currents with an apparently instantaneous activation, a rapid deactivation process and a linear current-voltage relationship and decreases the amplitude of the outward current . KCNQ1-KCNE2 channel associates with Na(+)-coupled myo-inositol symporter in the apical membrane of choroid plexus epithelium and regulates the myo-inositol gradient between blood and cerebrospinal fluid with an impact on neuron excitability. .

AccessionsQ9Y6J6
ENST00000290310.4
Q2N1I3