I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| endothelial cell | 3 studies | 19% ± 3% | |
| GABAergic neuron | 3 studies | 25% ± 9% | |
| glutamatergic neuron | 3 studies | 35% ± 11% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 3 studies | 19% ± 3% | |
| GABAergic neuron | 3 studies | 25% ± 9% | |
| glutamatergic neuron | 3 studies | 35% ± 11% |
Insufficient scRNA-seq data for expression of KCNC4 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 1630.10 | 1443 / 1445 | 94% | 3.86 | 172 / 183 |
| pancreas | 100% | 1802.76 | 327 / 328 | 93% | 3.93 | 165 / 178 |
| intestine | 100% | 1232.58 | 962 / 966 | 90% | 2.22 | 473 / 527 |
| stomach | 99% | 1148.77 | 356 / 359 | 89% | 2.47 | 255 / 286 |
| ovary | 100% | 1968.84 | 180 / 180 | 79% | 2.26 | 338 / 430 |
| uterus | 100% | 2528.14 | 170 / 170 | 74% | 2.18 | 338 / 459 |
| thymus | 100% | 1721.48 | 651 / 653 | 73% | 2.10 | 440 / 605 |
| kidney | 100% | 3644.08 | 89 / 89 | 72% | 2.22 | 649 / 901 |
| adrenal gland | 99% | 1105.48 | 255 / 258 | 73% | 5.06 | 167 / 230 |
| lung | 100% | 1711.38 | 578 / 578 | 70% | 1.71 | 807 / 1155 |
| brain | 98% | 2459.24 | 2578 / 2642 | 71% | 1.69 | 503 / 705 |
| breast | 100% | 2336.10 | 459 / 459 | 67% | 1.74 | 748 / 1118 |
| skin | 81% | 1616.06 | 1458 / 1809 | 81% | 1.90 | 384 / 472 |
| prostate | 100% | 2047.78 | 245 / 245 | 53% | 1.15 | 268 / 502 |
| bladder | 100% | 1496.33 | 21 / 21 | 47% | 0.95 | 235 / 504 |
| blood vessel | 100% | 1953.70 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| spleen | 100% | 1902.66 | 241 / 241 | 0% | 0 | 0 / 0 |
| adipose | 100% | 1607.84 | 1202 / 1204 | 0% | 0 | 0 / 0 |
| heart | 98% | 1028.51 | 841 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 98% | 2.69 | 78 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 93% | 2.33 | 27 / 29 |
| muscle | 92% | 898.02 | 736 / 803 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 82% | 2.42 | 37 / 45 |
| peripheral blood | 42% | 281.13 | 389 / 929 | 0% | 0 | 0 / 0 |
| liver | 21% | 107.23 | 48 / 226 | 15% | 0.39 | 59 / 406 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0051260 | Biological process | protein homooligomerization |
| GO_0006813 | Biological process | potassium ion transport |
| GO_0001508 | Biological process | action potential |
| GO_0007268 | Biological process | chemical synaptic transmission |
| GO_0071805 | Biological process | potassium ion transmembrane transport |
| GO_0043679 | Cellular component | axon terminus |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0008076 | Cellular component | voltage-gated potassium channel complex |
| GO_0032809 | Cellular component | neuronal cell body membrane |
| GO_0032590 | Cellular component | dendrite membrane |
| GO_0042734 | Cellular component | presynaptic membrane |
| GO_0045211 | Cellular component | postsynaptic membrane |
| GO_0005267 | Molecular function | potassium channel activity |
| GO_0005249 | Molecular function | voltage-gated potassium channel activity |
| GO_0005251 | Molecular function | delayed rectifier potassium channel activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | KCNC4 |
| Protein name | Potassium voltage-gated channel subfamily C member 4 Potassium voltage-gated channel subfamily C member 4 (KSHIIIC) (Voltage-gated potassium channel subunit Kv3.4) |
| Synonyms | C1orf30 |
| Description | FUNCTION: This protein mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. |
| Accessions | ENST00000369787.7 [Q03721-1] ENST00000438661.3 [Q03721-3] ENST00000469655.5 [Q03721-1] H7BZ66 A0A1B0GVB7 ENST00000413138.7 Q03721 ENST00000636402.1 |
