KCNA6 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of KCNA6 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of KCNA6 at tissue level.

III. Associated gene sets

GO_0051260Biological processprotein homooligomerization
GO_0006813Biological processpotassium ion transport
GO_0001508Biological processaction potential
GO_0071805Biological processpotassium ion transmembrane transport
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0034705Cellular componentpotassium channel complex
GO_0043679Cellular componentaxon terminus
GO_0005829Cellular componentcytosol
GO_0005886Cellular componentplasma membrane
GO_0008076Cellular componentvoltage-gated potassium channel complex
GO_0016020Cellular componentmembrane
GO_0005249Molecular functionvoltage-gated potassium channel activity
GO_0005251Molecular functiondelayed rectifier potassium channel activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameKCNA6
Protein namePotassium voltage-gated channel subfamily A member 6 (Voltage-gated potassium channel HBK2) (Voltage-gated potassium channel subunit Kv1.6)
Synonyms
DescriptionFUNCTION: Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient . The channel alternates between opened and closed conformations in response to the voltage difference across the membrane . Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA6, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (By similarity). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation (By similarity). Homotetrameric channels display rapid activation and slow inactivation . .

AccessionsP17658
ENST00000280684.4