KCNA4 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of KCNA4 at tissue level.

III. Associated gene sets

GO_0051260Biological processprotein homooligomerization
GO_0006813Biological processpotassium ion transport
GO_0001508Biological processaction potential
GO_0071805Biological processpotassium ion transmembrane transport
GO_0099505Biological processregulation of presynaptic membrane potential
GO_0030424Cellular componentaxon
GO_0043194Cellular componentaxon initial segment
GO_0043197Cellular componentdendritic spine
GO_0005886Cellular componentplasma membrane
GO_0008076Cellular componentvoltage-gated potassium channel complex
GO_0016020Cellular componentmembrane
GO_0030955Molecular functionpotassium ion binding
GO_0005249Molecular functionvoltage-gated potassium channel activity
GO_0005251Molecular functiondelayed rectifier potassium channel activity
GO_0005515Molecular functionprotein binding
GO_0099508Molecular functionvoltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

IV. Literature review

[source]
Gene nameKCNA4
Protein namePotassium voltage-gated channel subfamily A member 4 (HPCN2) (Voltage-gated K(+) channel HuKII) (Voltage-gated potassium channel HBK4) (Voltage-gated potassium channel HK1) (Voltage-gated potassium channel subunit Kv1.4)
SynonymsKCNA4L
DescriptionFUNCTION: Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane . Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel . Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Homotetrameric KCNA4 forms a potassium channel that opens in response to membrane depolarization, followed by rapid spontaneous channel closure . Likewise, a heterotetrameric channel formed by KCNA1 and KCNA4 shows rapid inactivation . .

AccessionsENST00000328224.7
P22459