KBTBD8 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of KBTBD8 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of KBTBD8 at tissue level.

III. Associated gene sets

GO_0014029Biological processneural crest formation
GO_0006513Biological processprotein monoubiquitination
GO_0014032Biological processneural crest cell development
GO_0006417Biological processregulation of translation
GO_0005819Cellular componentspindle
GO_0005829Cellular componentcytosol
GO_0031463Cellular componentCul3-RING ubiquitin ligase complex
GO_0005794Cellular componentGolgi apparatus
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameKBTBD8
Protein nameKelch repeat and BTB domain-containing protein 8 (T-cell activation kelch repeat protein) (TA-KRP)
Kelch repeat and BTB domain containing 8
SynonymsKIAA1842
TAKRP
DescriptionFUNCTION: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification . The BCR(KBTBD8) complex acts by mediating monoubiquitination of NOLC1 and TCOF1: monoubiquitination promotes the formation of a NOLC1-TCOF1 complex that acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification . .

AccessionsENST00000484414.5
ENST00000460576.5 [Q8NFY9-2]
Q8NFY9
C9JAA6
ENST00000460784.1
ENST00000417314.2 [Q8NFY9-1]
C9J331