KBTBD7 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of KBTBD7 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of KBTBD7 at tissue level.

III. Associated gene sets

GO_0070936Biological processprotein K48-linked ubiquitination
GO_0035020Biological processregulation of Rac protein signal transduction
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0009968Biological processnegative regulation of signal transduction
GO_0005829Cellular componentcytosol
GO_0031463Cellular componentCul3-RING ubiquitin ligase complex
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding
GO_0003674Molecular functionmolecular_function

IV. Literature review

[source]
Gene nameKBTBD7
Protein nameKelch repeat and BTB domain-containing protein 7
KBTBD7 protein
Synonyms
DescriptionFUNCTION: As part of the CUL3(KBTBD6/7) E3 ubiquitin ligase complex functions as a substrate adapter for the RAC1 guanine exchange factor (GEF) TIAM1, mediating its 'Lys-48' ubiquitination and proteasomal degradation . By controlling this ubiquitination, regulates RAC1 signal transduction and downstream biological processes including the organization of the cytoskeleton, cell migration and cell proliferation . Ubiquitination of TIAM1 requires the membrane-associated protein GABARAP which may restrict locally the activity of the complex . .

AccessionsENST00000379483.4
Q8WVZ9
Q6FI68