KBTBD6 | OmnibusX

Name	Number of supported studies	Average coverage
GABAergic neuron	3 studies	28% ± 3%	Explore
glutamatergic neuron	3 studies	29% ± 10%	Explore

Name	Number of supported studies	Average coverage
brain	3 studies	20% ± 3%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	2134.28	2642 / 2642	100%	30.03	704 / 705
prostate	99%	694.29	242 / 245	100%	13.32	501 / 502
thymus	99%	662.91	647 / 653	99%	11.73	597 / 605
breast	98%	561.44	450 / 459	99%	13.74	1112 / 1118
esophagus	97%	571.43	1405 / 1445	99%	13.09	182 / 183
uterus	99%	973.85	169 / 170	97%	10.11	446 / 459
bladder	100%	656.52	21 / 21	96%	8.54	484 / 504
adrenal gland	100%	1086.62	258 / 258	95%	21.62	218 / 230
intestine	98%	647.17	948 / 966	97%	9.27	509 / 527
ovary	98%	626.51	177 / 180	96%	8.13	411 / 430
stomach	95%	457.13	340 / 359	98%	10.01	279 / 286
pancreas	95%	429.67	312 / 328	97%	7.51	172 / 178
skin	96%	772.84	1733 / 1809	93%	13.58	441 / 472
kidney	97%	487.45	86 / 89	92%	8.46	832 / 901
lung	80%	385.05	461 / 578	97%	8.66	1125 / 1155
liver	95%	432.35	214 / 226	67%	3.48	273 / 406
spleen	100%	702.37	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	6.99	1 / 1
tonsil	0%	0	0 / 0	98%	10.00	44 / 45
adipose	96%	470.52	1157 / 1204	0%	0	0 / 0
blood vessel	95%	504.58	1267 / 1335	0%	0	0 / 0
heart	92%	614.75	795 / 861	0%	0	0 / 0
muscle	91%	389.69	730 / 803	0%	0	0 / 0
lymph node	0%	0	0 / 0	86%	6.40	25 / 29
eye	0%	0	0 / 0	78%	5.69	62 / 80
peripheral blood	60%	407.86	557 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0006986	Biological process	response to unfolded protein
GO_0070936	Biological process	protein K48-linked ubiquitination
GO_0043161	Biological process	proteasome-mediated ubiquitin-dependent protein catabolic process
GO_0035020	Biological process	regulation of Rac protein signal transduction
GO_0009968	Biological process	negative regulation of signal transduction
GO_0005829	Cellular component	cytosol
GO_0031463	Cellular component	Cul3-RING ubiquitin ligase complex
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0005515	Molecular function	protein binding
GO_0003674	Molecular function	molecular_function

Gene name	KBTBD6
Protein name	Alternative protein KBTBD6 Kelch repeat and BTB domain-containing protein 6
Synonyms
Description	FUNCTION: As part of the CUL3(KBTBD6/7) E3 ubiquitin ligase complex functions as a substrate adapter for the RAC1 guanine exchange factor (GEF) TIAM1, mediating its 'Lys-48' ubiquitination and proteasomal degradation . By controlling this ubiquitination, regulates RAC1 signal transduction and downstream biological processes including the organization of the cytoskeleton, cell migration and cell proliferation . Ubiquitination of TIAM1 requires the membrane-associated protein GABARAP which may restrict locally the activity of the complex . .
Accessions	Q86V97 ENST00000379485.2 L8ECN4

KBTBD6 report