Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 15 studies | 25% ± 5% | |
| CD16-positive, CD56-dim natural killer cell, human | 6 studies | 18% ± 3% | |
| epithelial cell | 4 studies | 29% ± 14% | |
| astrocyte | 4 studies | 21% ± 4% | |
| oligodendrocyte precursor cell | 4 studies | 23% ± 6% | |
| macrophage | 4 studies | 20% ± 3% | |
| oligodendrocyte | 4 studies | 18% ± 1% | |
| natural killer cell | 3 studies | 20% ± 3% | |
| myeloid cell | 3 studies | 20% ± 2% | |
| vein endothelial cell | 3 studies | 23% ± 7% | |
| GABAergic neuron | 3 studies | 31% ± 2% | |
| glutamatergic neuron | 3 studies | 39% ± 4% | |
| endothelial cell of vascular tree | 3 studies | 25% ± 5% | |
| microglial cell | 3 studies | 21% ± 4% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 5 studies | 29% ± 4% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| bladder | 100% | 2749.10 | 21 / 21 | 100% | 35.62 | 504 / 504 |
| breast | 100% | 3939.44 | 459 / 459 | 100% | 44.83 | 1118 / 1118 |
| esophagus | 100% | 2711.90 | 1445 / 1445 | 100% | 43.19 | 183 / 183 |
| lung | 100% | 4178.59 | 578 / 578 | 100% | 40.48 | 1155 / 1155 |
| stomach | 100% | 2040.04 | 359 / 359 | 100% | 34.50 | 286 / 286 |
| uterus | 100% | 3631.81 | 170 / 170 | 100% | 38.59 | 459 / 459 |
| brain | 100% | 2568.30 | 2641 / 2642 | 100% | 51.23 | 705 / 705 |
| thymus | 100% | 3595.13 | 653 / 653 | 100% | 40.28 | 604 / 605 |
| intestine | 100% | 3015.84 | 966 / 966 | 100% | 37.18 | 526 / 527 |
| prostate | 100% | 2676.92 | 245 / 245 | 100% | 24.62 | 500 / 502 |
| skin | 100% | 2954.53 | 1809 / 1809 | 99% | 57.05 | 469 / 472 |
| ovary | 100% | 2809.90 | 180 / 180 | 99% | 25.90 | 427 / 430 |
| kidney | 100% | 2138.64 | 89 / 89 | 99% | 34.63 | 891 / 901 |
| pancreas | 99% | 1208.20 | 324 / 328 | 99% | 36.36 | 176 / 178 |
| adrenal gland | 100% | 2455.34 | 258 / 258 | 97% | 25.81 | 224 / 230 |
| liver | 100% | 1351.46 | 226 / 226 | 97% | 19.22 | 392 / 406 |
| adipose | 100% | 4554.38 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 2981.36 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 29.33 | 29 / 29 |
| muscle | 100% | 4407.67 | 803 / 803 | 0% | 0 | 0 / 0 |
| spleen | 100% | 4651.81 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 40.06 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 14.15 | 1 / 1 |
| heart | 100% | 2072.14 | 860 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 96% | 33.04 | 77 / 80 |
| peripheral blood | 95% | 2214.34 | 884 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0043491 | Biological process | phosphatidylinositol 3-kinase/protein kinase B signal transduction |
| GO_0010467 | Biological process | gene expression |
| GO_0032868 | Biological process | response to insulin |
| GO_0070936 | Biological process | protein K48-linked ubiquitination |
| GO_0006629 | Biological process | lipid metabolic process |
| GO_1900076 | Biological process | regulation of cellular response to insulin stimulus |
| GO_0006006 | Biological process | glucose metabolic process |
| GO_0005737 | Cellular component | cytoplasm |
| GO_1990756 | Molecular function | ubiquitin-like ligase-substrate adaptor activity |
| Gene name | KBTBD2 |
| Protein name | Kelch repeat and BTB domain-containing protein 2 (BTB and kelch domain-containing protein 1) Kelch repeat and BTB (POZ) domain containing 2 Kelch repeat and BTB domain containing 2 |
| Synonyms | BKLHD1 CGI-73 tcag7.1209 KIAA1489 |
| Description | FUNCTION: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of the insulin signaling pathway, modulating insulin sensitivity by limiting PIK3R1/p85alpha abundance in adipocytes. Targets PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase (PI3K), for 'Lys-48'-linked polyubiquitination and proteasome-mediated degradation. . |
| Accessions | ENST00000304056.9 C9JZ29 A0A024RA38 ENST00000452926.1 C9JUE5 Q8IY47 ENST00000453627.1 ENST00000423022.1 C9JI11 |