Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 15 studies | 25% ± 5% | |
CD16-positive, CD56-dim natural killer cell, human | 6 studies | 18% ± 3% | |
epithelial cell | 4 studies | 29% ± 14% | |
astrocyte | 4 studies | 21% ± 4% | |
oligodendrocyte precursor cell | 4 studies | 23% ± 6% | |
macrophage | 4 studies | 20% ± 3% | |
oligodendrocyte | 4 studies | 18% ± 1% | |
natural killer cell | 3 studies | 20% ± 3% | |
myeloid cell | 3 studies | 20% ± 2% | |
vein endothelial cell | 3 studies | 23% ± 7% | |
GABAergic neuron | 3 studies | 31% ± 2% | |
glutamatergic neuron | 3 studies | 39% ± 4% | |
endothelial cell of vascular tree | 3 studies | 25% ± 5% | |
microglial cell | 3 studies | 21% ± 4% |
Name | Number of supported studies | Average coverage | |
---|---|---|---|
brain | 5 studies | 29% ± 4% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
bladder | 100% | 2749.10 | 21 / 21 | 100% | 35.62 | 504 / 504 |
breast | 100% | 3939.44 | 459 / 459 | 100% | 44.83 | 1118 / 1118 |
esophagus | 100% | 2711.90 | 1445 / 1445 | 100% | 43.19 | 183 / 183 |
lung | 100% | 4178.59 | 578 / 578 | 100% | 40.48 | 1155 / 1155 |
stomach | 100% | 2040.04 | 359 / 359 | 100% | 34.50 | 286 / 286 |
uterus | 100% | 3631.81 | 170 / 170 | 100% | 38.59 | 459 / 459 |
brain | 100% | 2568.30 | 2641 / 2642 | 100% | 51.23 | 705 / 705 |
thymus | 100% | 3595.13 | 653 / 653 | 100% | 40.28 | 604 / 605 |
intestine | 100% | 3015.84 | 966 / 966 | 100% | 37.18 | 526 / 527 |
prostate | 100% | 2676.92 | 245 / 245 | 100% | 24.62 | 500 / 502 |
skin | 100% | 2954.53 | 1809 / 1809 | 99% | 57.05 | 469 / 472 |
ovary | 100% | 2809.90 | 180 / 180 | 99% | 25.90 | 427 / 430 |
kidney | 100% | 2138.64 | 89 / 89 | 99% | 34.63 | 891 / 901 |
pancreas | 99% | 1208.20 | 324 / 328 | 99% | 36.36 | 176 / 178 |
adrenal gland | 100% | 2455.34 | 258 / 258 | 97% | 25.81 | 224 / 230 |
liver | 100% | 1351.46 | 226 / 226 | 97% | 19.22 | 392 / 406 |
adipose | 100% | 4554.38 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 2981.36 | 1335 / 1335 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 29.33 | 29 / 29 |
muscle | 100% | 4407.67 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 4651.81 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 40.06 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 14.15 | 1 / 1 |
heart | 100% | 2072.14 | 860 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 96% | 33.04 | 77 / 80 |
peripheral blood | 95% | 2214.34 | 884 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0043491 | Biological process | phosphatidylinositol 3-kinase/protein kinase B signal transduction |
GO_0010467 | Biological process | gene expression |
GO_0032868 | Biological process | response to insulin |
GO_0070936 | Biological process | protein K48-linked ubiquitination |
GO_0006629 | Biological process | lipid metabolic process |
GO_1900076 | Biological process | regulation of cellular response to insulin stimulus |
GO_0006006 | Biological process | glucose metabolic process |
GO_0005737 | Cellular component | cytoplasm |
GO_1990756 | Molecular function | ubiquitin-like ligase-substrate adaptor activity |
Gene name | KBTBD2 |
Protein name | Kelch repeat and BTB domain-containing protein 2 (BTB and kelch domain-containing protein 1) Kelch repeat and BTB (POZ) domain containing 2 Kelch repeat and BTB domain containing 2 |
Synonyms | BKLHD1 CGI-73 tcag7.1209 KIAA1489 |
Description | FUNCTION: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of the insulin signaling pathway, modulating insulin sensitivity by limiting PIK3R1/p85alpha abundance in adipocytes. Targets PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase (PI3K), for 'Lys-48'-linked polyubiquitination and proteasome-mediated degradation. . |
Accessions | ENST00000304056.9 C9JZ29 A0A024RA38 ENST00000452926.1 C9JUE5 Q8IY47 ENST00000453627.1 ENST00000423022.1 C9JI11 |