KBTBD2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0043491Biological processphosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0010467Biological processgene expression
GO_0032868Biological processresponse to insulin
GO_0070936Biological processprotein K48-linked ubiquitination
GO_0006629Biological processlipid metabolic process
GO_1900076Biological processregulation of cellular response to insulin stimulus
GO_0006006Biological processglucose metabolic process
GO_0005737Cellular componentcytoplasm
GO_1990756Molecular functionubiquitin-like ligase-substrate adaptor activity

IV. Literature review

[source]
Gene nameKBTBD2
Protein nameKelch repeat and BTB domain-containing protein 2 (BTB and kelch domain-containing protein 1)
Kelch repeat and BTB (POZ) domain containing 2
Kelch repeat and BTB domain containing 2
SynonymsBKLHD1
CGI-73
tcag7.1209
KIAA1489
DescriptionFUNCTION: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of the insulin signaling pathway, modulating insulin sensitivity by limiting PIK3R1/p85alpha abundance in adipocytes. Targets PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase (PI3K), for 'Lys-48'-linked polyubiquitination and proteasome-mediated degradation. .

AccessionsENST00000304056.9
C9JZ29
A0A024RA38
ENST00000452926.1
C9JUE5
Q8IY47
ENST00000453627.1
ENST00000423022.1
C9JI11