KATNB1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of KATNB1 at tissue level.

III. Associated gene sets

GO_0007019Biological processmicrotubule depolymerization
GO_0031122Biological processcytoplasmic microtubule organization
GO_0010976Biological processpositive regulation of neuron projection development
GO_0051013Biological processmicrotubule severing
GO_0051301Biological processcell division
GO_0006605Biological processprotein targeting
GO_0007026Biological processnegative regulation of microtubule depolymerization
GO_0031117Biological processpositive regulation of microtubule depolymerization
GO_0007079Biological processmitotic chromosome movement towards spindle pole
GO_0043065Biological processpositive regulation of apoptotic process
GO_0030496Cellular componentmidbody
GO_0005886Cellular componentplasma membrane
GO_0005874Cellular componentmicrotubule
GO_0000922Cellular componentspindle pole
GO_0016020Cellular componentmembrane
GO_0005813Cellular componentcentrosome
GO_0043025Cellular componentneuronal cell body
GO_0005829Cellular componentcytosol
GO_0015630Cellular componentmicrotubule cytoskeleton
GO_0008352Cellular componentkatanin complex
GO_0030426Cellular componentgrowth cone
GO_0005737Cellular componentcytoplasm
GO_0005819Cellular componentspindle
GO_0005634Cellular componentnucleus
GO_0060590Molecular functionATPase regulator activity
GO_0008017Molecular functionmicrotubule binding
GO_0046982Molecular functionprotein heterodimerization activity
GO_0070840Molecular functiondynein complex binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameKATNB1
Protein nameKatanin p80 WD40 repeat-containing subunit B1 (Katanin p80 subunit B1) (p80 katanin)
Katanin regulatory subunit B1
Synonyms
DescriptionFUNCTION: Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth. .

AccessionsH3BPK1
ENST00000569627.1
H3BPD8
Q9BVA0
ENST00000566785.5
ENST00000566726.5
ENST00000562592.5
H3BTU7
H3BT67
H3BTV8
ENST00000563462.1
ENST00000379661.8