KATNA1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0031122Biological processcytoplasmic microtubule organization
GO_0051013Biological processmicrotubule severing
GO_0051301Biological processcell division
GO_0097431Cellular componentmitotic spindle pole
GO_0030496Cellular componentmidbody
GO_0005874Cellular componentmicrotubule
GO_0000922Cellular componentspindle pole
GO_0005813Cellular componentcentrosome
GO_0015630Cellular componentmicrotubule cytoskeleton
GO_0008352Cellular componentkatanin complex
GO_0005737Cellular componentcytoplasm
GO_0005819Cellular componentspindle
GO_0008568Molecular functionmicrotubule severing ATPase activity
GO_0008017Molecular functionmicrotubule binding
GO_0005524Molecular functionATP binding
GO_0046982Molecular functionprotein heterodimerization activity
GO_0016853Molecular functionisomerase activity
GO_0005515Molecular functionprotein binding
GO_0016887Molecular functionATP hydrolysis activity

IV. Literature review

[source]
Gene nameKATNA1
Protein nameMultifunctional fusion protein [Includes: Katanin p60 ATPase-containing subunit A1 (Katanin p60 subunit A1) (EC 5.6.1.1) (p60 katanin); Katanin p60 ATPase-containing subunit A-like 1 (Katanin p60 subunit A-like 1) (p60 katanin-like 1)]
Katanin catalytic subunit A1
Katanin p60 ATPase-containing subunit A1 (Katanin p60 subunit A1) (EC 5.6.1.1) (p60 katanin)
SynonymsKATNAL1
DescriptionFUNCTION: Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth. .; FUNCTION: Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility. Severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubule arrays. .

FUNCTION: Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth. .

FUNCTION: Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth. .

AccessionsENST00000367411.7 [O75449-1]
ENST00000335643.12 [O75449-2]
ENST00000444282.5
ENST00000335647.9 [O75449-1]
ENST00000420200.1
O75449
A8K7S5
B7ZBC9
B3KUK7
B7ZBC8