IYD report

I. Expression across cell types

Insufficient scRNA-seq data for expression of IYD at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of IYD at tissue level.

III. Associated gene sets

GO_0006570Biological processtyrosine metabolic process
GO_0042403Biological processthyroid hormone metabolic process
GO_0005654Cellular componentnucleoplasm
GO_0005886Cellular componentplasma membrane
GO_0030659Cellular componentcytoplasmic vesicle membrane
GO_0016491Molecular functionoxidoreductase activity
GO_0010181Molecular functionFMN binding
GO_0140616Molecular functioniodotyrosine deiodinase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameIYD
Protein nameIodotyrosine deiodinase
Iodotyrosine deiodinase 1 (IYD-1) (EC 1.21.1.1) (Iodotyrosine dehalogenase 1)
Iodotyrosine deiodinase 1 (EC 1.21.1.1) (Iodotyrosine dehalogenase 1)
SynonymsC6orf71
DEHAL1
DescriptionFUNCTION: Catalyzes the dehalogenation of halotyrosines such as 3-bromo-L-tyrosine, 3-chloro-L-tyrosine, 3-iodo-L-tyrosine and 3,5-diiodo-L-tyrosine . During thyroid hormone biosynthesis, facilitates iodide salvage by catalysing the oxidative NADPH-dependent deiodination of the halogenated by-products of thyroid hormone production, monoiodotyrosine (L-MIT) and diiodotyrosine (L-DIT) . The scavanged iodide can then reenter the hormone-producing pathways . Acts more efficiently on 3-iodo-L-tyrosine than 3,5-diiodo-L-tyrosine . .

AccessionsENST00000392255.7
A0A5P9KEU5
ENST00000344419.8 [Q6PHW0-1]
Q6PHW0
ENST00000229447.9 [Q6PHW0-4]
ENST00000367335.7 [Q6PHW0-3]
ENST00000500320.7
ENST00000392256.6 [Q6PHW0-3]
F6VN83
F5H543
C9JXJ9
ENST00000425615.3
H7C0X6
ENST00000422583.2