ITLN1 | OmnibusX

Name	Number of supported studies	Average coverage
goblet cell	11 studies	65% ± 16%	Explore
mesothelial cell	8 studies	74% ± 17%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of ITLN1 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
intestine	56%	2730.63	538 / 966	69%	180.86	366 / 527
stomach	45%	674.69	160 / 359	63%	113.15	181 / 286
ureter	0%	0	0 / 0	100%	70.38	1 / 1
blood vessel	74%	3013.65	991 / 1335	0%	0	0 / 0
ovary	49%	458.53	88 / 180	22%	8.03	95 / 430
lung	25%	1880.88	146 / 578	21%	81.50	241 / 1155
adipose	41%	16314.79	488 / 1204	0%	0	0 / 0
heart	40%	4653.90	347 / 861	0%	0	0 / 0
pancreas	1%	8.93	2 / 328	39%	114.18	69 / 178
bladder	0%	0	0 / 21	38%	88.77	194 / 504
esophagus	2%	9.15	34 / 1445	32%	75.73	59 / 183
lymph node	0%	0	0 / 0	24%	1.25	7 / 29
peripheral blood	18%	277.97	170 / 929	0%	0	0 / 0
liver	5%	12.99	12 / 226	9%	0.99	35 / 406
kidney	9%	108.15	8 / 89	4%	0.49	36 / 901
uterus	1%	12.51	2 / 170	8%	2.67	37 / 459
prostate	1%	1.84	2 / 245	7%	0.35	37 / 502
eye	0%	0	0 / 0	8%	1.67	6 / 80
thymus	3%	22.73	20 / 653	3%	0.45	18 / 605
skin	0%	2.52	5 / 1809	6%	0.95	26 / 472
adrenal gland	0%	1.62	1 / 258	5%	0.72	12 / 230
spleen	5%	85.84	11 / 241	0%	0	0 / 0
breast	3%	15.86	16 / 459	1%	0.07	11 / 1118
muscle	2%	9.93	18 / 803	0%	0	0 / 0
tonsil	0%	0	0 / 0	2%	0.05	1 / 45
brain	0%	0.25	3 / 2642	1%	0.27	8 / 705
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0009624	Biological process	response to nematode
GO_0070207	Biological process	protein homotrimerization
GO_0046326	Biological process	positive regulation of glucose import
GO_0001934	Biological process	positive regulation of protein phosphorylation
GO_0031526	Cellular component	brush border membrane
GO_0005615	Cellular component	extracellular space
GO_0098552	Cellular component	side of membrane
GO_0070062	Cellular component	extracellular exosome
GO_0043235	Cellular component	receptor complex
GO_0005576	Cellular component	extracellular region
GO_0045121	Cellular component	membrane raft
GO_0070492	Molecular function	oligosaccharide binding
GO_0005509	Molecular function	calcium ion binding
GO_0042802	Molecular function	identical protein binding
GO_0005515	Molecular function	protein binding

Gene name	ITLN1
Protein name	Intelectin-1 (ITLN-1) (Endothelial lectin HL-1) (Galactofuranose-binding lectin) (Intestinal lactoferrin receptor) (Omentin) Intelectin 1 (Intelectin variant)
Synonyms	ITLN INTL LFR UNQ640/PRO1270
Description	FUNCTION: Lectin that specifically recognizes microbial carbohydrate chains in a calcium-dependent manner . Binds to microbial glycans that contain a terminal acyclic 1,2-diol moiety, including beta-linked D-galactofuranose (beta-Galf), D-phosphoglycerol-modified glycans, D-glycero-D-talo-oct-2-ulosonic acid (KO) and 3-deoxy-D-manno-oct-2-ulosonic acid (KDO) . Binds to glycans from Gram-positive and Gram-negative bacteria, including K.pneumoniae, S.pneumoniae, Y.pestis, P.mirabilis and P.vulgaris . Does not bind human glycans . Probably plays a role in the defense system against microorganisms (Probable). May function as adipokine that has no effect on basal glucose uptake but enhances insulin-stimulated glucose uptake in adipocytes . Increases AKT phosphorylation in the absence and presence of insulin . May interact with lactoferrin/LTF and increase its uptake, and may thereby play a role in iron absorption . .
Accessions	ENST00000326245.4 Q5IWS5 Q8WWA0

ITLN1 report