Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| smooth muscle cell | 23 studies | 28% ± 11% | |
| pericyte | 13 studies | 25% ± 7% | |
| astrocyte | 9 studies | 55% ± 21% | |
| myofibroblast cell | 7 studies | 23% ± 4% | |
| fibroblast | 3 studies | 26% ± 10% | |
| muscle cell | 3 studies | 50% ± 29% |
Insufficient scRNA-seq data for expression of IRAG1 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| prostate | 97% | 11709.55 | 238 / 245 | 97% | 24.18 | 488 / 502 |
| brain | 76% | 6349.32 | 2016 / 2642 | 99% | 35.70 | 699 / 705 |
| esophagus | 85% | 18704.99 | 1222 / 1445 | 86% | 14.72 | 158 / 183 |
| breast | 85% | 4589.98 | 388 / 459 | 86% | 8.70 | 962 / 1118 |
| bladder | 100% | 12901.95 | 21 / 21 | 70% | 8.49 | 353 / 504 |
| intestine | 85% | 12786.25 | 822 / 966 | 83% | 10.94 | 435 / 527 |
| stomach | 73% | 8136.50 | 263 / 359 | 91% | 18.20 | 259 / 286 |
| lung | 69% | 3277.39 | 400 / 578 | 78% | 9.39 | 906 / 1155 |
| uterus | 99% | 16426.73 | 168 / 170 | 49% | 9.39 | 223 / 459 |
| ovary | 76% | 5261.14 | 137 / 180 | 57% | 4.65 | 243 / 430 |
| thymus | 52% | 2324.85 | 337 / 653 | 61% | 3.66 | 368 / 605 |
| kidney | 29% | 1392.62 | 26 / 89 | 72% | 13.97 | 647 / 901 |
| blood vessel | 100% | 38722.21 | 1334 / 1335 | 0% | 0 | 0 / 0 |
| adrenal gland | 21% | 745.06 | 55 / 258 | 75% | 7.01 | 172 / 230 |
| pancreas | 0% | 8.81 | 1 / 328 | 94% | 18.60 | 168 / 178 |
| adipose | 84% | 6617.08 | 1007 / 1204 | 0% | 0 | 0 / 0 |
| skin | 21% | 894.85 | 372 / 1809 | 21% | 1.13 | 98 / 472 |
| peripheral blood | 38% | 3668.88 | 350 / 929 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 33% | 1.82 | 15 / 45 |
| spleen | 23% | 905.54 | 55 / 241 | 0% | 0 | 0 / 0 |
| liver | 0% | 0 | 0 / 226 | 22% | 1.58 | 89 / 406 |
| heart | 16% | 626.48 | 137 / 861 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 10% | 0.35 | 3 / 29 |
| muscle | 4% | 170.17 | 32 / 803 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 4% | 0.17 | 3 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0019934 | Biological process | cGMP-mediated signaling |
| GO_0016529 | Cellular component | sarcoplasmic reticulum |
| GO_0031095 | Cellular component | platelet dense tubular network membrane |
| GO_0048471 | Cellular component | perinuclear region of cytoplasm |
| GO_0005789 | Cellular component | endoplasmic reticulum membrane |
| GO_0005515 | Molecular function | protein binding |
| Gene name | IRAG1 |
| Protein name | Inositol 1,4,5-triphosphate receptor associated 1 (Inositol 1,4,5-trisphosphate receptor-associated cGMP kinase substrate) (JAW1-related protein MRVI1) (Protein MRVI1) Inositol 1,4,5-triphosphate receptor associated 1 |
| Synonyms | MRVI1 JAW1L IRAG |
| Description | FUNCTION: Plays a role as NO/PRKG1-dependent regulator of IP3-induced calcium release; its phosphorylation by PRKG1 inhibits bradykinin and IP3-induced calcium release from intracellular stores. Recruits PRKG1 to the endoplasmic reticulum and may mediate the assembly of PRKG1 and ITPR1 in a macrocomplex. Involved in PRKG1 signaling cascade leading to inhibition of platelet activation and aggregation. Mediates also NO-dependent inhibition of calcium signaling in gastrointestinal smooth muscle contributing to NO-dependent relaxation. . |
| Accessions | ENST00000531308.1 ENST00000526414.5 ENST00000529068.5 E9PNK7 ENST00000423302.7 [Q9Y6F6-7] ENST00000533631.1 H0YDM7 E9PRG4 ENST00000547195.5 [Q9Y6F6-6] ENST00000558540.5 [Q9Y6F6-6] H0YCL0 E9PRH0 E9PJ61 ENST00000534266.6 [Q9Y6F6-6] ENST00000531107.5 [Q9Y6F6-9] Q9Y6F6 ENST00000424001.5 [Q9Y6F6-6] ENST00000541483.5 [Q9Y6F6-8] ENST00000529448.5 ENST00000529547.1 |
