IPPK report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0032958Biological processinositol phosphate biosynthetic process
GO_1901838Biological processpositive regulation of transcription of nucleolar large rRNA by RNA polymerase I
GO_0043647Biological processinositol phosphate metabolic process
GO_0005730Cellular componentnucleolus
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding
GO_0035299Molecular functioninositol pentakisphosphate 2-kinase activity
GO_0060090Molecular functionmolecular adaptor activity
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene nameIPPK
Protein nameInositol-pentakisphosphate 2-kinase (EC 2.7.1.158) (IPK1 homolog) (Inositol-1,3,4,5,6-pentakisphosphate 2-kinase) (Ins(1,3,4,5,6)P5 2-kinase) (InsP5 2-kinase)
Inositol-pentakisphosphate 2-kinase (EC 2.7.1.158)
SynonymsC9orf12
DescriptionFUNCTION: Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). InsP6 is involved in many processes such as mRNA export, non-homologous end-joining, endocytosis, ion channel regulation. It also protects cells from TNF-alpha-induced apoptosis. .

FUNCTION: Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). .

AccessionsENST00000287996.8
ENST00000375522.2
X6R9A6
Q9H8X2