IPO9 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006606Biological processprotein import into nucleus
GO_0031144Biological processproteasome localization
GO_0005829Cellular componentcytosol
GO_0005635Cellular componentnuclear envelope
GO_0016020Cellular componentmembrane
GO_0005737Cellular componentcytoplasm
GO_0061608Molecular functionnuclear import signal receptor activity
GO_0005515Molecular functionprotein binding
GO_0140713Molecular functionhistone chaperone activity
GO_0031267Molecular functionsmall GTPase binding
GO_0042393Molecular functionhistone binding

IV. Literature review

[source]
Gene nameIPO9
Protein nameImportin-9 (Imp9) (Ran-binding protein 9) (RanBP9)
Importin 9
SynonymsKIAA1192
RANBP9
IMP9
HSPC273
DescriptionFUNCTION: Nuclear transport receptor that mediates nuclear import of proteins, such as histones, proteasome and actin . Serves as receptor for nuclear localization signals (NLS) in cargo substrates . Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism . At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran . The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus . Mediates the import of pre-assembled proteasomes into the nucleus; AKIRIN2 acts as a molecular bridge between IPO9 and the proteasome complex . Mediates the nuclear import of histones H2A, H2B, H4 and H4 . In addition to nuclear import, also acts as a chaperone for histones by preventing inappropriate non-nucleosomal interactions . Mediates the nuclear import of actin (By similarity). .

AccessionsENST00000456707.1
Q5SVH5
Q96P70
ENST00000361565.9