INPP5J report

I. Expression across cell types

Insufficient scRNA-seq data for expression of INPP5J at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of INPP5J at tissue level.

III. Associated gene sets

GO_0033137Biological processnegative regulation of peptidyl-serine phosphorylation
GO_0010977Biological processnegative regulation of neuron projection development
GO_0046856Biological processphosphatidylinositol dephosphorylation
GO_0006661Biological processphosphatidylinositol biosynthetic process
GO_0043647Biological processinositol phosphate metabolic process
GO_0001726Cellular componentruffle
GO_0043198Cellular componentdendritic shaft
GO_0005829Cellular componentcytosol
GO_0005886Cellular componentplasma membrane
GO_0030426Cellular componentgrowth cone
GO_0005737Cellular componentcytoplasm
GO_0004445Molecular functioninositol-polyphosphate 5-phosphatase activity
GO_0052659Molecular functioninositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity
GO_0052658Molecular functioninositol-1,4,5-trisphosphate 5-phosphatase activity
GO_0034485Molecular functionphosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity
GO_0005515Molecular functionprotein binding
GO_0004439Molecular functionphosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
GO_0017124Molecular functionSH3 domain binding

IV. Literature review

[source]
Gene nameINPP5J
Protein nameInositol polyphosphate-5-phosphatase J
inositol-polyphosphate 5-phosphatase (EC 3.1.3.56)
Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (EC 3.1.3.36) (Inositol polyphosphate 5-phosphatase J) (Phosphatidylinositol 1,3,4,5-tetrakisphosphate 5-phosphatase) (EC 3.1.3.56) (Phosphatidylinositol 1,4,5-trisphosphate 5-phosphatase) (EC 3.1.3.56)
Inositol polyphosphate-5-phosphatase J (cDNA FLJ59315, highly similar to Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A)
SynonymsPIB5PA
PIPP
DescriptionFUNCTION: Inositol 5-phosphatase, which converts inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate. Also converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4-phosphate and inositol 1,3,4,5-tetrakisphosphate to inositol 1,3,4-trisphosphate in vitro. May be involved in modulation of the function of inositol and phosphatidylinositol polyphosphate-binding proteins that are present at membranes ruffles. .

AccessionsENST00000400294.6 [Q15735-2]
ENST00000405300.5 [Q15735-2]
ENST00000412277.6
B5MBZ3
ENST00000404390.7 [Q15735-3]
ENST00000412985.5
ENST00000404453.5
ENST00000402238.5
ENST00000331075.10 [Q15735-1]
ENST00000420017.5
A0A087WVS7
Q15735
B4DF95
ENST00000620191.4
B5MCL8
C9K0M5
ENST00000401755.1
C9J0H5