ING5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1903706Biological processregulation of hemopoiesis
GO_0097190Biological processapoptotic signaling pathway
GO_0008285Biological processnegative regulation of cell population proliferation
GO_0048147Biological processnegative regulation of fibroblast proliferation
GO_0001558Biological processregulation of cell growth
GO_0140889Biological processDNA replication-dependent chromatin disassembly
GO_0048144Biological processfibroblast proliferation
GO_0006355Biological processregulation of DNA-templated transcription
GO_2000278Biological processregulation of DNA biosynthetic process
GO_2001235Biological processpositive regulation of apoptotic signaling pathway
GO_0006473Biological processprotein acetylation
GO_0006275Biological processregulation of DNA replication
GO_0045926Biological processnegative regulation of growth
GO_0043065Biological processpositive regulation of apoptotic process
GO_0050793Biological processregulation of developmental process
GO_0051726Biological processregulation of cell cycle
GO_0005654Cellular componentnucleoplasm
GO_0070776Cellular componentMOZ/MORF histone acetyltransferase complex
GO_0000123Cellular componenthistone acetyltransferase complex
GO_0005634Cellular componentnucleus
GO_0035064Molecular functionmethylated histone binding
GO_0003682Molecular functionchromatin binding
GO_0046872Molecular functionmetal ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameING5
Protein nameInhibitor of growth family member 5
Inhibitor of growth protein 5 (p28ING5)
Synonyms
DescriptionFUNCTION: Component of the HBO1 complex, which specifically mediates acetylation of histone H3 at 'Lys-14' (H3K14ac) and, to a lower extent, acetylation of histone H4 . Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity . Through chromatin acetylation it may regulate DNA replication and may function as a transcriptional coactivator . Inhibits cell growth, induces a delay in S-phase progression and enhances Fas-induced apoptosis in an INCA1-dependent manner . .

AccessionsA0A1B0GW41
E9PEN0
ENST00000636051.1
ENST00000445620.5
Q8WYH8
ENST00000406941.5 [Q8WYH8-2]
ENST00000313552.11 [Q8WYH8-1]