ING3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_2000779Biological processregulation of double-strand break repair
GO_0006338Biological processchromatin remodeling
GO_0042981Biological processregulation of apoptotic process
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0006355Biological processregulation of DNA-templated transcription
GO_1905168Biological processpositive regulation of double-strand break repair via homologous recombination
GO_0051726Biological processregulation of cell cycle
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0000812Cellular componentSwr1 complex
GO_0000786Cellular componentnucleosome
GO_0005654Cellular componentnucleoplasm
GO_0035267Cellular componentNuA4 histone acetyltransferase complex
GO_0032777Cellular componentpiccolo histone acetyltransferase complex
GO_0005634Cellular componentnucleus
GO_0035064Molecular functionmethylated histone binding
GO_0043997Molecular functionhistone H4K12 acetyltransferase activity
GO_0046972Molecular functionhistone H4K16 acetyltransferase activity
GO_0043996Molecular functionhistone H4K8 acetyltransferase activity
GO_0010485Molecular functionhistone H4 acetyltransferase activity
GO_0043995Molecular functionhistone H4K5 acetyltransferase activity
GO_0046872Molecular functionmetal ion binding
GO_0043998Molecular functionhistone H2A acetyltransferase activity

IV. Literature review

[source]
Gene nameING3
Protein nameInhibitor of growth protein 3 (p47ING3)
ING3 protein
Inhibitor of growth protein
Inhibitor of growth family member 3
SynonymsHSPC301
DescriptionFUNCTION: Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. .

FUNCTION: Component of an histone acetyltransferase complex. .

AccessionsA0A0C4DG38
ENST00000315870.10 [Q9NXR8-1]
ENST00000431467.1
Q9NXR8
E7ET07
B7ZKQ7
ENST00000445699.5
ENST00000427726.5 [Q9NXR8-3]
ENST00000339121.9 [Q9NXR8-2]