I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| glutamatergic neuron | 3 studies | 17% ± 1% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| glutamatergic neuron | 3 studies | 17% ± 1% |
Insufficient scRNA-seq data for expression of INCENP at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 1287.62 | 1438 / 1445 | 100% | 37.99 | 183 / 183 |
| skin | 100% | 1560.88 | 1809 / 1809 | 99% | 45.89 | 469 / 472 |
| intestine | 100% | 712.36 | 964 / 966 | 99% | 29.07 | 522 / 527 |
| stomach | 100% | 579.08 | 358 / 359 | 99% | 30.57 | 283 / 286 |
| ovary | 100% | 565.20 | 180 / 180 | 98% | 23.35 | 422 / 430 |
| lung | 99% | 624.41 | 575 / 578 | 98% | 25.41 | 1129 / 1155 |
| bladder | 100% | 596.52 | 21 / 21 | 97% | 25.66 | 490 / 504 |
| uterus | 100% | 693.58 | 170 / 170 | 97% | 29.33 | 443 / 459 |
| breast | 100% | 652.34 | 458 / 459 | 96% | 21.36 | 1077 / 1118 |
| brain | 95% | 756.59 | 2515 / 2642 | 97% | 17.65 | 686 / 705 |
| thymus | 100% | 1161.99 | 653 / 653 | 91% | 14.35 | 551 / 605 |
| pancreas | 96% | 367.05 | 315 / 328 | 93% | 13.02 | 165 / 178 |
| prostate | 100% | 492.13 | 245 / 245 | 82% | 8.69 | 411 / 502 |
| kidney | 96% | 357.63 | 85 / 89 | 76% | 7.96 | 685 / 901 |
| adrenal gland | 95% | 522.17 | 246 / 258 | 56% | 5.20 | 128 / 230 |
| liver | 70% | 194.84 | 159 / 226 | 54% | 5.99 | 219 / 406 |
| spleen | 100% | 877.05 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 38.63 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 8.64 | 1 / 1 |
| blood vessel | 100% | 542.43 | 1330 / 1335 | 0% | 0 | 0 / 0 |
| adipose | 100% | 586.28 | 1198 / 1204 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 98% | 18.81 | 78 / 80 |
| muscle | 96% | 485.18 | 774 / 803 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 93% | 34.95 | 27 / 29 |
| heart | 79% | 262.79 | 681 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 65% | 1204.71 | 603 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0000278 | Biological process | mitotic cell cycle |
| GO_0007059 | Biological process | chromosome segregation |
| GO_0051310 | Biological process | metaphase chromosome alignment |
| GO_1901970 | Biological process | positive regulation of mitotic sister chromatid separation |
| GO_0000281 | Biological process | mitotic cytokinesis |
| GO_0090307 | Biological process | mitotic spindle assembly |
| GO_0051256 | Biological process | mitotic spindle midzone assembly |
| GO_0090267 | Biological process | positive regulation of mitotic cell cycle spindle assembly checkpoint |
| GO_0051257 | Biological process | meiotic spindle midzone assembly |
| GO_1902425 | Biological process | positive regulation of attachment of mitotic spindle microtubules to kinetochore |
| GO_1903490 | Biological process | positive regulation of mitotic cytokinesis |
| GO_0000775 | Cellular component | chromosome, centromeric region |
| GO_0000801 | Cellular component | central element |
| GO_0030496 | Cellular component | midbody |
| GO_0010369 | Cellular component | chromocenter |
| GO_0005874 | Cellular component | microtubule |
| GO_0000776 | Cellular component | kinetochore |
| GO_0032991 | Cellular component | protein-containing complex |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0032133 | Cellular component | chromosome passenger complex |
| GO_1990385 | Cellular component | meiotic spindle midzone |
| GO_0016604 | Cellular component | nuclear body |
| GO_0005829 | Cellular component | cytosol |
| GO_0015630 | Cellular component | microtubule cytoskeleton |
| GO_0005721 | Cellular component | pericentric heterochromatin |
| GO_0000800 | Cellular component | lateral element |
| GO_0005819 | Cellular component | spindle |
| GO_0005634 | Cellular component | nucleus |
| GO_0140677 | Molecular function | molecular function activator activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | INCENP |
| Protein name | Inner centromere protein |
| Synonyms | |
| Description | FUNCTION: Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Acts as a scaffold regulating CPC localization and activity. The C-terminus associates with AURKB or AURKC, the N-terminus associated with BIRC5/survivin and CDCA8/borealin tethers the CPC to the inner centromere, and the microtubule binding activity within the central SAH domain directs AURKB/C toward substrates near microtubules . The flexibility of the SAH domain is proposed to allow AURKB/C to follow substrates on dynamic microtubules while ensuring CPC docking to static chromatin (By similarity). Activates AURKB and AURKC . Required for localization of CBX5 to mitotic centromeres . Controls the kinetochore localization of BUB1 . . |
| Accessions | ENST00000533896.5 Q9NQS7 ENST00000278849.4 [Q9NQS7-2] ENST00000394818.8 [Q9NQS7-1] E9PM67 |
