INCA1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of INCA1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of INCA1 at tissue level.

III. Associated gene sets

GO_0097190Biological processapoptotic signaling pathway
GO_0008285Biological processnegative regulation of cell population proliferation
GO_2001235Biological processpositive regulation of apoptotic signaling pathway
GO_0045736Biological processnegative regulation of cyclin-dependent protein serine/threonine kinase activity
GO_0048147Biological processnegative regulation of fibroblast proliferation
GO_0048144Biological processfibroblast proliferation
GO_0016604Cellular componentnuclear body
GO_0005654Cellular componentnucleoplasm
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0044877Molecular functionprotein-containing complex binding
GO_0004861Molecular functioncyclin-dependent protein serine/threonine kinase inhibitor activity
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding
GO_0030332Molecular functioncyclin binding

IV. Literature review

[source]
Gene nameINCA1
Protein nameProtein INCA1 (Inhibitor of CDK interacting with cyclin A1)
SynonymsHSD45
DescriptionFUNCTION: Binds to CDK2-bound cyclins and inhibits the kinase activity of CDK2; binding to cyclins is critical for its function as CDK inhibitor . Inhibits cell growth and cell proliferation and may play a role in cell cycle control (By similarity). Required for ING5-mediated regulation of S-phase progression, enhancement of Fas-induced apoptosis and inhibition of cell growth (By similarity). .

AccessionsENST00000355025.7 [Q0VD86-2]
ENST00000574617.1 [Q0VD86-1]
ENST00000695324.1 [Q0VD86-1]
Q0VD86
ENST00000576820.5 [Q0VD86-1]
ENST00000575780.5 [Q0VD86-2]