ILDR1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of ILDR1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ILDR1 at tissue level.

III. Associated gene sets

GO_0010669Biological processepithelial structure maintenance
GO_0070542Biological processresponse to fatty acid
GO_1990830Biological processcellular response to leukemia inhibitory factor
GO_0090277Biological processpositive regulation of peptide hormone secretion
GO_0051649Biological processestablishment of localization in cell
GO_0061833Biological processprotein localization to tricellular tight junction
GO_0016192Biological processvesicle-mediated transport
GO_1904274Biological processtricellular tight junction assembly
GO_0030072Biological processpeptide hormone secretion
GO_0043484Biological processregulation of RNA splicing
GO_0070160Cellular componenttight junction
GO_0005886Cellular componentplasma membrane
GO_0032991Cellular componentprotein-containing complex
GO_0005829Cellular componentcytosol
GO_0005923Cellular componentbicellular tight junction
GO_0061689Cellular componenttricellular tight junction
GO_0042802Molecular functionidentical protein binding
GO_0070506Molecular functionhigh-density lipoprotein particle receptor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameILDR1
Protein nameImmunoglobulin-like domain-containing receptor 1 (Angulin-2)
Synonyms
DescriptionFUNCTION: Maintains epithelial barrier function by recruiting MARVELD2/tricellulin to tricellular tight junctions (tTJs) . Crucial for normal hearing by maintaining the structural and functional integrity of tTJs, which are critical for the survival of auditory neurosensory HCs. Mediates fatty acids and lipoproteins-stimulated CCK/cholecystokinin secretion in the small intestine. In the inner ear, may regulate alternative pre-mRNA splicing via binding to TRA2A, TRA2B and SRSF1 (By similarity). .; FUNCTION: (Microbial infection) Promotes influenza virus infection by inhibiting viral nucleoprotein NP binding to PLSCR1 and thereby PLSCR1-mediated antiviral activity. .

AccessionsENST00000273691.7 [Q86SU0-2]
ENST00000393631.5 [Q86SU0-5]
ENST00000642615.1 [Q86SU0-3]
ENST00000344209.10 [Q86SU0-1]
Q86SU0