IL22RA2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of IL22RA2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of IL22RA2 at tissue level.

III. Associated gene sets

GO_0019221Biological processcytokine-mediated signaling pathway
GO_0050728Biological processnegative regulation of inflammatory response
GO_0042509Biological processregulation of tyrosine phosphorylation of STAT protein
GO_0140865Biological processinterleukin-22-mediated signaling pathway
GO_0005615Cellular componentextracellular space
GO_0005829Cellular componentcytosol
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0042018Molecular functioninterleukin-22 receptor activity
GO_0042017Molecular functioninterleukin-22 binding

IV. Literature review

[source]
Gene nameIL22RA2
Protein nameInterleukin-22 receptor subunit alpha-2 (IL-22 receptor subunit alpha-2) (IL-22R-alpha-2) (IL-22RA2) (Cytokine receptor class-II member 10) (Cytokine receptor family 2 member 10) (CRF2-10) (Cytokine receptor family type 2, soluble 1) (CRF2-S1) (Interleukin-22-binding protein) (IL-22BP) (IL22BP) (ZcytoR16)
SynonymsUNQ5793/PRO19598/PRO19822
DescriptionFUNCTION: Isoform 2 is a receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of inflammatory responses.; FUNCTION: Isoform 1 may play a role in establishing and maintaining successful pregnancy.

AccessionsENST00000339602.3 [Q969J5-3]
ENST00000349184.9 [Q969J5-2]
Q969J5
ENST00000296980.7 [Q969J5-1]