IL17RD report

I. Expression across cell types

Insufficient scRNA-seq data for expression of IL17RD at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of IL17RD at tissue level.

III. Associated gene sets

GO_0019221Biological processcytokine-mediated signaling pathway
GO_0010719Biological processnegative regulation of epithelial to mesenchymal transition
GO_0030512Biological processnegative regulation of transforming growth factor beta receptor signaling pathway
GO_0000139Cellular componentGolgi membrane
GO_0005654Cellular componentnucleoplasm
GO_0005794Cellular componentGolgi apparatus
GO_0005886Cellular componentplasma membrane
GO_0030368Molecular functioninterleukin-17 receptor activity

IV. Literature review

[source]
Gene nameIL17RD
Protein nameInterleukin 17 receptor D
Interleukin-17 receptor D (IL-17 receptor D) (IL-17RD) (IL17Rhom) (Interleukin-17 receptor-like protein) (Sef homolog) (hSef)
SynonymsSEF
IL17RLM
UNQ6115/PRO20026
DescriptionFUNCTION: Feedback inhibitor of fibroblast growth factor mediated Ras-MAPK signaling and ERK activation . Regulates the nuclear ERK signaling pathway by spatially blocking nuclear translocation of activated ERK without inhibiting cytoplasmic phosphorylation of ERK . Mediates JNK activation and may be involved in apoptosis (By similarity). May inhibit FGF-induced FGFR1 tyrosine phosphorylation (By similarity). Might have a role in the early stages of fate specification of GnRH-secreting neurons (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity). .

AccessionsENST00000467210.5
ENST00000296318.12 [Q8NFM7-1]
ENST00000320057.9 [Q8NFM7-2]
Q8NFM7
ENST00000463523.5 [Q8NFM7-2]
C9J6R0