I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| fibroblast | 9 studies | 20% ± 5% | |
| endothelial cell | 5 studies | 18% ± 2% | |
| capillary endothelial cell | 4 studies | 20% ± 3% | |
| endothelial cell of artery | 3 studies | 21% ± 6% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| fibroblast | 9 studies | 20% ± 5% | |
| endothelial cell | 5 studies | 18% ± 2% | |
| capillary endothelial cell | 4 studies | 20% ± 3% | |
| endothelial cell of artery | 3 studies | 21% ± 6% |
Insufficient scRNA-seq data for expression of IL15RA at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| stomach | 100% | 978.30 | 359 / 359 | 100% | 22.60 | 286 / 286 |
| esophagus | 100% | 1082.48 | 1442 / 1445 | 100% | 22.08 | 183 / 183 |
| intestine | 100% | 1148.85 | 965 / 966 | 100% | 21.82 | 526 / 527 |
| lung | 100% | 4168.58 | 578 / 578 | 99% | 20.54 | 1147 / 1155 |
| thymus | 100% | 1241.22 | 652 / 653 | 95% | 8.06 | 573 / 605 |
| liver | 99% | 1134.61 | 224 / 226 | 95% | 17.69 | 387 / 406 |
| breast | 100% | 1961.00 | 459 / 459 | 93% | 11.17 | 1045 / 1118 |
| pancreas | 95% | 811.74 | 313 / 328 | 97% | 27.02 | 172 / 178 |
| uterus | 100% | 1996.01 | 170 / 170 | 91% | 19.95 | 416 / 459 |
| bladder | 100% | 1629.33 | 21 / 21 | 89% | 17.90 | 448 / 504 |
| prostate | 99% | 1088.07 | 243 / 245 | 89% | 5.77 | 446 / 502 |
| kidney | 94% | 774.20 | 84 / 89 | 75% | 12.72 | 673 / 901 |
| adrenal gland | 99% | 646.69 | 255 / 258 | 62% | 4.34 | 142 / 230 |
| skin | 93% | 760.26 | 1683 / 1809 | 65% | 6.46 | 306 / 472 |
| ovary | 70% | 375.08 | 126 / 180 | 86% | 11.28 | 369 / 430 |
| adipose | 100% | 1819.60 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 32.24 | 29 / 29 |
| spleen | 100% | 1360.98 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 21.36 | 45 / 45 |
| heart | 100% | 1005.78 | 858 / 861 | 0% | 0 | 0 / 0 |
| blood vessel | 96% | 861.79 | 1279 / 1335 | 0% | 0 | 0 / 0 |
| muscle | 92% | 437.25 | 737 / 803 | 0% | 0 | 0 / 0 |
| peripheral blood | 70% | 543.72 | 646 / 929 | 0% | 0 | 0 / 0 |
| brain | 17% | 68.21 | 461 / 2642 | 38% | 2.13 | 265 / 705 |
| eye | 0% | 0 | 0 / 0 | 11% | 0.63 | 9 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0050766 | Biological process | positive regulation of phagocytosis |
| GO_0035723 | Biological process | interleukin-15-mediated signaling pathway |
| GO_0001779 | Biological process | natural killer cell differentiation |
| GO_0031667 | Biological process | response to nutrient levels |
| GO_0032825 | Biological process | positive regulation of natural killer cell differentiation |
| GO_0010977 | Biological process | negative regulation of neuron projection development |
| GO_0007259 | Biological process | cell surface receptor signaling pathway via JAK-STAT |
| GO_0005576 | Cellular component | extracellular region |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0005789 | Cellular component | endoplasmic reticulum membrane |
| GO_0009986 | Cellular component | cell surface |
| GO_0000139 | Cellular component | Golgi membrane |
| GO_0005768 | Cellular component | endosome |
| GO_0031965 | Cellular component | nuclear membrane |
| GO_0030659 | Cellular component | cytoplasmic vesicle membrane |
| GO_0019901 | Molecular function | protein kinase binding |
| GO_0042010 | Molecular function | interleukin-15 receptor activity |
| GO_0004896 | Molecular function | cytokine receptor activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | IL15RA |
| Protein name | IL15RA protein Interleukin 15 receptor alpha isoform EM2 (Interleukin 15 receptor subunit alpha) Interleukin 15 receptor alpha isoform IC5 (Interleukin 15 receptor subunit alpha) Interleukin 15 receptor alpha isoform IC2 (Interleukin 15 receptor subunit alpha) Interleukin 15 receptor alpha isoform IC3 (Interleukin 15 receptor subunit alpha) Interleukin 15 receptor alpha Interleukin 15 receptor subunit alpha Interleukin-15 receptor subunit alpha (IL-15 receptor subunit alpha) (IL-15R-alpha) (IL-15RA) (CD antigen CD215) [Cleaved into: Soluble interleukin-15 receptor subunit alpha (sIL-15 receptor subunit alpha) (sIL-15R-alpha) (sIL-15RA)] |
| Synonyms | il15ra |
| Description | FUNCTION: High-affinity receptor for interleukin-15 . Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells (By similarity). In neutrophils, binds and activates kinase SYK in response to IL15 stimulation . In neutrophils, required for IL15-induced phagocytosis in a SYK-dependent manner . Expression of different isoforms may alter or interfere with signal transduction . .; FUNCTION: [Isoform 5]: Does not bind IL15. .; FUNCTION: [Isoform 6]: Does not bind IL15. .; FUNCTION: [Isoform 7]: Does not bind IL15. .; FUNCTION: [Isoform 8]: Does not bind IL15. . |
| Accessions | K9N2Q6 K9N2S2 ENST00000379971.5 [Q13261-9] E9PQ64 ENST00000397251.7 K9N1J3 H0YD11 K9N163 H0Y4R3 ENST00000620345.4 Q5JVA3 ENST00000530685.5 [Q13261-5] ENST00000528354.5 [Q13261-3] ENST00000397255.7 [Q13261-4] ENST00000525219.6 [Q13261-10] E7ETI1 ENST00000532039.5 ENST00000397248.6 Q6P0Q3 ENST00000435171.6 G8CVM3 A0A0A0MS77 ENST00000620865.4 ENST00000447291.5 ENST00000397250.6 [Q13261-8] ENST00000622442.4 ENST00000429135.2 ENST00000397246.7 ENST00000379977.8 [Q13261-1] Q13261 H0Y6E8 ENST00000453922.1 |
