Insufficient scRNA-seq data for expression of IHO1 at tissue level.
Tissue | GTEx Coverage  | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| skin | 96% | 127.37 | 1729 / 1809 | 40% | 1.19 | 190 / 472 |
| breast | 100% | 236.16 | 459 / 459 | 14% | 0.24 | 159 / 1118 |
| adrenal gland | 99% | 177.09 | 255 / 258 | 14% | 0.37 | 32 / 230 |
| ovary | 100% | 451.77 | 180 / 180 | 7% | 0.13 | 30 / 430 |
| uterus | 99% | 170.46 | 169 / 170 | 7% | 0.26 | 30 / 459 |
| thymus | 100% | 151.27 | 650 / 653 | 6% | 0.08 | 35 / 605 |
| adipose | 100% | 216.89 | 1203 / 1204 | 0% | 0 | 0 / 0 |
| lung | 93% | 75.89 | 536 / 578 | 6% | 0.12 | 68 / 1155 |
| blood vessel | 97% | 104.14 | 1300 / 1335 | 0% | 0 | 0 / 0 |
| bladder | 95% | 107.86 | 20 / 21 | 1% | 0.03 | 7 / 504 |
| heart | 94% | 91.35 | 811 / 861 | 0% | 0 | 0 / 0 |
| muscle | 91% | 64.08 | 729 / 803 | 0% | 0 | 0 / 0 |
| esophagus | 82% | 102.12 | 1189 / 1445 | 7% | 0.14 | 13 / 183 |
| prostate | 85% | 54.52 | 209 / 245 | 0% | 0.01 | 2 / 502 |
| intestine | 82% | 95.05 | 793 / 966 | 2% | 0.03 | 12 / 527 |
| spleen | 75% | 40.34 | 181 / 241 | 0% | 0 | 0 / 0 |
| kidney | 56% | 24.27 | 50 / 89 | 6% | 0.12 | 56 / 901 |
| stomach | 44% | 32.99 | 157 / 359 | 7% | 0.14 | 21 / 286 |
| peripheral blood | 31% | 17.47 | 289 / 929 | 0% | 0 | 0 / 0 |
| brain | 27% | 10.37 | 714 / 2642 | 1% | 0.03 | 9 / 705 |
| pancreas | 5% | 1.44 | 15 / 328 | 4% | 0.08 | 7 / 178 |
| liver | 5% | 2.36 | 11 / 226 | 3% | 0.06 | 12 / 406 |
| eye | 0% | 0 | 0 / 0 | 5% | 0.07 | 4 / 80 |
| tonsil | 0% | 0 | 0 / 0 | 2% | 0.07 | 1 / 45 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0006310 | Biological process | DNA recombination |
| GO_0007283 | Biological process | spermatogenesis |
| GO_0042138 | Biological process | meiotic DNA double-strand break formation |
| GO_0048477 | Biological process | oogenesis |
| GO_0060629 | Biological process | regulation of homologous chromosome segregation |
| GO_0007129 | Biological process | homologous chromosome pairing at meiosis |
| GO_0000794 | Cellular component | condensed nuclear chromosome |
| GO_0005515 | Molecular function | protein binding |
| Gene name | IHO1 |
| Protein name | Interactor of HORMAD1 protein 1 (Cancer/testis antigen 74) (CT74) (Coiled-coil domain-containing protein 36) |
| Synonyms | CCDC36 |
| Description | FUNCTION: Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance. . |
| Accessions | ENST00000438782.5 [Q8IYA8-1] Q8IYA8 ENST00000296449.9 [Q8IYA8-1] ENST00000366429.2 [Q8IYA8-3] ENST00000452691.7 [Q8IYA8-1] |
