IGSF8 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0048870Biological processcell motility
GO_0007399Biological processnervous system development
GO_0007338Biological processsingle fertilization
GO_0007519Biological processskeletal muscle tissue development
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0070062Cellular componentextracellular exosome
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameIGSF8
Protein nameImmunoglobulin superfamily member 8 (IgSF8) (CD81 partner 3) (Glu-Trp-Ile EWI motif-containing protein 2) (EWI-2) (Keratinocytes-associated transmembrane protein 4) (KCT-4) (LIR-D1) (Prostaglandin regulatory-like protein) (PGRL) (CD antigen CD316)
Immunoglobulin superfamily member 8
SynonymsEWI2
KCT4
CD81P3
DescriptionFUNCTION: May play a key role in diverse functions ascribed to CD81 and CD9 such as oocytes fertilization or hepatitis C virus function. May regulate proliferation and differentiation of keratinocytes. May be a negative regulator of cell motility: suppresses T-cell mobility coordinately with CD81, associates with CD82 to suppress prostate cancer cell migration, regulates epidermoid cell reaggregation and motility on laminin-5 with CD9 and CD81 as key linkers. May also play a role on integrin-dependent morphology and motility functions. May participate in the regulation of neurite outgrowth and maintenance of the neural network in the adult brain. .

AccessionsENST00000614243.4 [Q969P0-1]
C9J8Z4
ENST00000314485.12 [Q969P0-1]
ENST00000368086.5 [Q969P0-1]
ENST00000448417.1
Q969P0