IFT56 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0060271Biological processcilium assembly
GO_0061512Biological processprotein localization to cilium
GO_0015031Biological processprotein transport
GO_0007224Biological processsmoothened signaling pathway
GO_1905198Biological processmanchette assembly
GO_0035720Biological processintraciliary anterograde transport
GO_0042073Biological processintraciliary transport
GO_0035735Biological processintraciliary transport involved in cilium assembly
GO_0035082Biological processaxoneme assembly
GO_0097542Cellular componentciliary tip
GO_0005813Cellular componentcentrosome
GO_0005929Cellular componentcilium
GO_0036064Cellular componentciliary basal body
GO_0030992Cellular componentintraciliary transport particle B
GO_0043005Cellular componentneuron projection
GO_0097546Cellular componentciliary base
GO_0120170Molecular functionintraciliary transport particle B binding

IV. Literature review

[source]
Gene nameIFT56
Protein nameIntraflagellar transport protein 56 (Tetratricopeptide repeat protein 26)
Intraflagellar transport protein 56 (Tetratricopeptide repeat protein 26) (TPR repeat protein 26)
Alternative protein TTC26
SynonymsFLJ12571
hCG_16387
TTC26
DescriptionFUNCTION: Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium. Required for transport of specific ciliary cargo proteins related to motility, while it is neither required for IFT complex B assembly or motion nor for cilium assembly. Required for efficient coupling between the accumulation of GLI2 and GLI3 at the ciliary tips and their dissociation from the negative regulator SUFU. Plays a key role in maintaining the integrity of the IFT complex B and the proper ciliary localization of the IFT complex B components. Not required for IFT complex A ciliary localization or function. Essential for maintaining proper microtubule organization within the ciliary axoneme. .

AccessionsB7Z2T3
F8WEZ4
ENST00000478836.6
B7Z6R6
ENST00000474035.6
ENST00000476296.1
ENST00000430935.5 [A0AVF1-2]
Q96CU4
L8EC83
ENST00000343187.8 [A0AVF1-3]
ENST00000495038.5
ENST00000464848.5 [A0AVF1-1]
A0AVF1