IFI30 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0019886Biological processantigen processing and presentation of exogenous peptide antigen via MHC class II
GO_0048147Biological processnegative regulation of fibroblast proliferation
GO_0050821Biological processprotein stabilization
GO_0042590Biological processantigen processing and presentation of exogenous peptide antigen via MHC class I
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0030054Cellular componentcell junction
GO_0043202Cellular componentlysosomal lumen
GO_0005764Cellular componentlysosome
GO_0005829Cellular componentcytosol
GO_0005576Cellular componentextracellular region
GO_0016671Molecular functionoxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor
GO_0016667Molecular functionoxidoreductase activity, acting on a sulfur group of donors
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameIFI30
Protein nameInterferon gamma-inducible protein 30
Gamma-interferon-inducible lysosomal thiol reductase (EC 1.8.-.-) (Gamma-interferon-inducible protein IP-30) (Legumaturain)
Gamma-interferon-inducible lysosomal thiol reductase (EC 1.8.-.-) (Gamma-interferon-inducible protein IP-30)
SynonymsIP30
GILT
DescriptionFUNCTION: Lysosomal thiol reductase that can reduce protein disulfide bonds. May facilitate the complete unfolding of proteins destined for lysosomal degradation. Plays an important role in antigen processing. Facilitates the generation of MHC class II-restricted epitodes from disulfide bond-containing antigen by the endocytic reduction of disulfide bonds (By similarity). Facilitates also MHC class I-restricted recognition of exogenous antigens containing disulfide bonds by CD8+ T-cells or crosspresentation (By similarity). .

FUNCTION: Lysosomal thiol reductase that can reduce protein disulfide bonds. Facilitates the complete unfolding of proteins destined for lysosomal degradation. Plays an important role in antigen processing. .

AccessionsQ96P99
ENST00000597802.2
P13284
M0QZG3
ENST00000407280.4