IBSP report

I. Expression across cell types

Insufficient scRNA-seq data for expression of IBSP at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of IBSP at tissue level.

III. Associated gene sets

GO_0030198Biological processextracellular matrix organization
GO_0007155Biological processcell adhesion
GO_0045785Biological processpositive regulation of cell adhesion
GO_0071363Biological processcellular response to growth factor stimulus
GO_0030282Biological processbone mineralization
GO_0001649Biological processosteoblast differentiation
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0031982Cellular componentvesicle
GO_0016020Cellular componentmembrane
GO_0036094Molecular functionsmall molecule binding
GO_0005178Molecular functionintegrin binding
GO_0005515Molecular functionprotein binding
GO_0003674Molecular functionmolecular_function

IV. Literature review

[source]
Gene nameIBSP
Protein nameIntegrin-binding sialoprotein (Bone sialoprotein 2) (Bone sialoprotein II) (BSP II) (Cell-binding sialoprotein)
SynonymsBNSP
DescriptionFUNCTION: Binds tightly to hydroxyapatite . Appears to form an integral part of the mineralized matrix . Probably important to cell-matrix interaction . Promotes adhesion and migration of various cells via the alpha-V/beta-3 integrin receptor (ITGAV:ITGB3) . .

AccessionsENST00000226284.7
P21815