HTRA3 | OmnibusX

sc-RNAseq data

Insufficient scRNA-seq data for expression of HTRA3 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	99%	5637.63	455 / 459	92%	119.63	1026 / 1118
lung	98%	4303.99	569 / 578	89%	70.04	1032 / 1155
intestine	92%	2894.04	884 / 966	81%	58.79	427 / 527
uterus	99%	4497.98	169 / 170	66%	55.78	305 / 459
esophagus	83%	4164.99	1200 / 1445	82%	61.09	150 / 183
bladder	90%	6865.57	19 / 21	68%	59.44	343 / 504
prostate	92%	3090.90	225 / 245	67%	22.80	334 / 502
stomach	68%	1955.30	245 / 359	84%	61.30	240 / 286
ovary	100%	9941.07	180 / 180	46%	18.00	196 / 430
thymus	97%	3230.55	635 / 653	37%	14.41	221 / 605
skin	74%	2093.92	1344 / 1809	41%	22.52	194 / 472
pancreas	10%	156.27	32 / 328	93%	210.84	165 / 178
ureter	0%	0	0 / 0	100%	17.68	1 / 1
heart	100%	11230.33	859 / 861	0%	0	0 / 0
adipose	100%	7007.96	1201 / 1204	0%	0	0 / 0
muscle	90%	1592.79	719 / 803	0%	0	0 / 0
blood vessel	62%	2170.56	828 / 1335	0%	0	0 / 0
tonsil	0%	0	0 / 0	56%	36.35	25 / 45
adrenal gland	31%	372.50	79 / 258	11%	5.46	26 / 230
lymph node	0%	0	0 / 0	41%	20.44	12 / 29
kidney	20%	271.06	18 / 89	12%	3.43	105 / 901
liver	1%	31.01	3 / 226	20%	8.83	83 / 406
eye	0%	0	0 / 0	16%	3.55	13 / 80
peripheral blood	8%	84.15	74 / 929	0%	0	0 / 0
brain	0%	0	0 / 2642	8%	2.19	56 / 705
spleen	5%	56.41	12 / 241	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0030514	Biological process	negative regulation of BMP signaling pathway
GO_0030512	Biological process	negative regulation of transforming growth factor beta receptor signaling pathway
GO_0006508	Biological process	proteolysis
GO_0005576	Cellular component	extracellular region
GO_0008236	Molecular function	serine-type peptidase activity
GO_0004175	Molecular function	endopeptidase activity
GO_0042802	Molecular function	identical protein binding
GO_0005515	Molecular function	protein binding
GO_0004252	Molecular function	serine-type endopeptidase activity

Gene name	HTRA3
Protein name	Serine protease HTRA3 (EC 3.4.21.-) (High-temperature requirement factor A3) (Pregnancy-related serine protease)
Synonyms	PRSP
Description	FUNCTION: Serine protease that cleaves beta-casein/CSN2 as well as several extracellular matrix (ECM) proteoglycans such as decorin/DCN, biglycan/BGN and fibronectin/FN1. Inhibits signaling mediated by TGF-beta family proteins possibly indirectly by degradation of these ECM proteoglycans (By similarity). May act as a tumor suppressor. Negatively regulates, in vitro, trophoblast invasion during placental development and may be involved in the development of the placenta in vivo. May also have a role in ovarian development, granulosa cell differentiation and luteinization . .
Accessions	P83110 ENST00000382512.3 [P83110-2] ENST00000307358.7 [P83110-1]

HTRA3 report