HSF2BP report

I. Expression across cell types

Insufficient scRNA-seq data for expression of HSF2BP at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of HSF2BP at tissue level.

III. Associated gene sets

GO_0006366Biological processtranscription by RNA polymerase II
GO_0007283Biological processspermatogenesis
GO_1990918Biological processdouble-strand break repair involved in meiotic recombination
GO_0007141Biological processmale meiosis I
GO_0007144Biological processfemale meiosis I
GO_0005694Cellular componentchromosome
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameHSF2BP
Protein nameHeat shock factor 2-binding protein
HSF2BP protein (Heat shock transcription factor 2 binding protein, isoform CRA_b) (cDNA, FLJ94816, Homo sapiens heat shock transcription factor 2 binding protein(HSF2BP), mRNA)
Heat shock transcription factor 2 binding protein
SynonymshCG_2007376
MEILB2
DescriptionFUNCTION: Meiotic recombination factor component of recombination bridges involved in meiotic double-strand break repair. Modulates the localization of recombinases DMC1:RAD51 to meiotic double-strand break (DSB) sites through the interaction with BRCA2 and its recruitment during meiotic recombination (By similarity) . Indispensable for the DSB repair, homologous synapsis, and crossover formation that are needed for progression past metaphase I, is essential for spermatogenesis and male fertility (By similarity). Required for proper recombinase recruitment in female meiosis (By similarity). Inhibits BNC1 transcriptional activity during spermatogenesis, probably by sequestering it in the cytoplasm (By similarity). May be involved in modulating HSF2 activation in testis . .

AccessionsENST00000443485.1
ENST00000291560.7 [O75031-1]
Q6IAT7
O75031
C9JSF2