HSD17B3 | OmnibusX

Name	Number of supported studies	Average coverage
oligodendrocyte	5 studies	22% ± 5%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of HSD17B3 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Number of samples
kidney	100%	215.85	89 / 89	0%	0 / 901
liver	100%	417.73	226 / 226	0%	0 / 406
thymus	100%	563.71	650 / 653	0%	0 / 605
intestine	98%	148.65	951 / 966	0%	0 / 527
prostate	98%	181.78	241 / 245	0%	0 / 502
pancreas	98%	127.63	320 / 328	0%	0 / 178
uterus	94%	113.25	160 / 170	0%	0 / 459
breast	93%	99.09	425 / 459	0%	0 / 1118
lung	92%	101.63	533 / 578	0%	0 / 1155
heart	88%	90.80	761 / 861	0%	0 / 0
brain	88%	177.36	2312 / 2642	0%	0 / 705
blood vessel	87%	80.54	1168 / 1335	0%	0 / 0
ovary	84%	75.06	152 / 180	0%	0 / 430
adipose	84%	75.89	1016 / 1204	0%	0 / 0
bladder	81%	87.19	17 / 21	0%	0 / 504
esophagus	73%	103.11	1048 / 1445	0%	0 / 183
stomach	71%	56.51	254 / 359	0%	0 / 286
spleen	59%	41.67	142 / 241	0%	0 / 0
adrenal gland	50%	33.63	130 / 258	0%	0 / 230
skin	44%	30.98	788 / 1809	0%	0 / 472
muscle	21%	12.40	167 / 803	0%	0 / 0
peripheral blood	1%	0.59	11 / 929	0%	0 / 0
abdomen	0%	0	0 / 0	0%	0 / 0
bone marrow	0%	0	0 / 0	0%	0 / 0
diaphragm	0%	0	0 / 0	0%	0 / 0
eye	0%	0	0 / 0	0%	0 / 80
gingiva	0%	0	0 / 0	0%	0 / 0
lymph node	0%	0	0 / 0	0%	0 / 29
nasal cavity	0%	0	0 / 0	0%	0 / 0
nasopharynx	0%	0	0 / 0	0%	0 / 0
nose	0%	0	0 / 0	0%	0 / 0
placenta	0%	0	0 / 0	0%	0 / 0
spinal column	0%	0	0 / 0	0%	0 / 0
tonsil	0%	0	0 / 0	0%	0 / 45
ureter	0%	0	0 / 0	0%	0 / 1

GO_0030539	Biological process	male genitalia development
GO_0061370	Biological process	testosterone biosynthetic process
GO_0006702	Biological process	androgen biosynthetic process
GO_0006694	Biological process	steroid biosynthetic process
GO_0043231	Cellular component	intracellular membrane-bounded organelle
GO_0005783	Cellular component	endoplasmic reticulum
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0047045	Molecular function	testosterone 17-beta-dehydrogenase (NADP+) activity
GO_0004303	Molecular function	estradiol 17-beta-dehydrogenase [NAD(P)+] activity
GO_0030283	Molecular function	testosterone dehydrogenase [NAD(P)+] activity
GO_0072582	Molecular function	17-beta-hydroxysteroid dehydrogenase (NADP+) activity

Gene name	HSD17B3
Protein name	17beta-estradiol 17-dehydrogenase (EC 1.1.1.62) Hydroxysteroid 17-beta dehydrogenase 3 (Hydroxysteroid dehydrogenase 3 isoform 5) Hydroxysteroid 17-beta dehydrogenase 3 17-beta-hydroxysteroid dehydrogenase type 3 (17-beta-HSD 3) (Estradiol 17-beta-dehydrogenase 2) (EC 1.1.1.62) (Short chain dehydrogenase/reductase family 12C member 2) (Testicular 17-beta-hydroxysteroid dehydrogenase) (Testosterone 17-beta-dehydrogenase 3) (EC 1.1.1.64)
Synonyms	SDR12C2 hCG_33005 EDH17B3
Description	FUNCTION: Catalyzes the conversion of 17-oxosteroids to 17beta-hydroxysteroids . Favors the reduction of androstenedione to testosterone . Testosterone is the key androgen driving male development and function . Uses NADPH while the two other EDH17B enzymes use NADH . Androgens such as epiandrosterone, dehydroepiandrosterone, androsterone and androstanedione are accepted as substrates and reduced at C-17 . Can reduce 11-ketoandrostenedione as well as 11beta-hydroxyandrostenedione at C-17 to the respective testosterone forms . .
Accessions	A0A0S2Z3V7 A0A0S2Z413 ENST00000648146.1 A0A0S2Z3U6 ENST00000375263.8 [P37058-1] P37058 ENST00000648799.1 Q6FH62 ENST00000648332.1 A0A3B3ITW2 ENST00000650386.1 ENST00000467499.6 A0A3B3ITT4 A0A0S2Z406 ENST00000650005.1 ENST00000375262.4 [P37058-2]

HSD17B3 report