HSD17B1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007040Biological processlysosome organization
GO_0006703Biological processestrogen biosynthetic process
GO_0007519Biological processskeletal muscle tissue development
GO_0061370Biological processtestosterone biosynthetic process
GO_0006694Biological processsteroid biosynthetic process
GO_0071248Biological processcellular response to metal ion
GO_0060612Biological processadipose tissue development
GO_0008210Biological processestrogen metabolic process
GO_0010467Biological processgene expression
GO_0060348Biological processbone development
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0042803Molecular functionprotein homodimerization activity
GO_0003824Molecular functioncatalytic activity
GO_0047035Molecular functiontestosterone dehydrogenase (NAD+) activity
GO_0072582Molecular function17-beta-hydroxysteroid dehydrogenase (NADP+) activity
GO_0036094Molecular functionsmall molecule binding
GO_0047045Molecular functiontestosterone 17-beta-dehydrogenase (NADP+) activity
GO_0004303Molecular functionestradiol 17-beta-dehydrogenase [NAD(P)+] activity
GO_0050661Molecular functionNADP binding
GO_0030283Molecular functiontestosterone dehydrogenase [NAD(P)+] activity
GO_0005496Molecular functionsteroid binding
GO_0035410Molecular functiondihydrotestosterone 17-beta-dehydrogenase activity
GO_0005515Molecular functionprotein binding
GO_0070401Molecular functionNADP+ binding
GO_1903924Molecular functionestradiol binding

IV. Literature review

[source]
Gene nameHSD17B1
Protein nameEstradiol 17-beta-dehydrogenase (EC 1.1.1.62)
Hydroxysteroid 17-beta dehydrogenase 1 (cDNA FLJ50217, highly similar to Estradiol 17-beta-dehydrogenase 1)
17-beta-hydroxysteroid dehydrogenase type 1 (17-beta-HSD 1) (EC 1.1.1.51) (20 alpha-hydroxysteroid dehydrogenase) (20-alpha-HSD) (E2DH) (Estradiol 17-beta-dehydrogenase 1) (EC 1.1.1.62) (Placental 17-beta-hydroxysteroid dehydrogenase) (Short chain dehydrogenase/reductase family 28C member 1)
SynonymsSDR28C1
EDHB17
EDH17B1
E17KSR
EDH17B2
DescriptionFUNCTION: Favors the reduction of estrogens and androgens. Converts estrone (E1) to a more potent estrogen, 17beta-estradiol (E2) . Also has 20-alpha-HSD activity. Uses preferentially NADH. .

FUNCTION: Favors the reduction of estrogens and androgens. Uses preferentially NADH. .

AccessionsENST00000590299.5
ENST00000225929.5
ENST00000585807.6
A0A0A0MQS7
P14061
B4DU11