HSD11B1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of HSD11B1 at tissue level.

III. Associated gene sets

GO_0006706Biological processsteroid catabolic process
GO_0030324Biological processlung development
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0070524Molecular function11-beta-hydroxysteroid dehydrogenase (NADP+) activity
GO_0042803Molecular functionprotein homodimerization activity
GO_0050661Molecular functionNADP binding
GO_0047022Molecular function7-beta-hydroxysteroid dehydrogenase (NADP+) activity
GO_0102196Molecular functioncortisol dehydrogenase activity
GO_0005496Molecular functionsteroid binding

IV. Literature review

[source]
Gene nameHSD11B1
Protein nameHydroxysteroid 11-beta dehydrogenase 1
11-beta-hydroxysteroid dehydrogenase 1 (11-DH) (11-beta-HSD1) (EC 1.1.1.146) (7-oxosteroid reductase) (EC 1.1.1.201) (Corticosteroid 11-beta-dehydrogenase isozyme 1) (Short chain dehydrogenase/reductase family 26C member 1)
11-beta-hydroxysteroid dehydrogenase 1 (EC 1.1.1.146) (EC 1.1.1.201) (7-oxosteroid reductase) (Corticosteroid 11-beta-dehydrogenase isozyme 1)
SynonymsSDR26C1
HSD11L
HSD11
DescriptionFUNCTION: Controls the reversible conversion of biologically active glucocorticoids such as cortisone to cortisol, and 11-dehydrocorticosterone to corticosterone in the presence of NADP(H) . Participates in the corticosteroid receptor-mediated anti-inflammatory response, as well as metabolic and homeostatic processes . Plays a role in the secretion of aqueous humor in the eye, maintaining a normotensive, intraocular environment . Bidirectional in vitro, predominantly functions as a reductase in vivo, thereby increasing the concentration of active glucocorticoids . It has broad substrate specificity, besides glucocorticoids, it accepts other steroid and sterol substrates . Interconverts 7-oxo- and 7-hydroxy-neurosteroids such as 7-oxopregnenolone and 7beta-hydroxypregnenolone, 7-oxodehydroepiandrosterone (3beta-hydroxy-5-androstene-7,17-dione) and 7beta-hydroxydehydroepiandrosterone (3beta,7beta-dihydroxyandrost-5-en-17-one), among others . Catalyzes the stereo-specific conversion of the major dietary oxysterol, 7-ketocholesterol (7-oxocholesterol), into the more polar 7-beta-hydroxycholesterol metabolite . 7-oxocholesterol is one of the most important oxysterols, it participates in several events such as induction of apoptosis, accumulation in atherosclerotic lesions, lipid peroxidation, and induction of foam cell formation . Mediates the 7-oxo reduction of 7-oxolithocholate mainly to chenodeoxycholate, and to a lesser extent to ursodeoxycholate, both in its free form and when conjugated to glycine or taurine, providing a link between glucocorticoid activation and bile acid metabolism . Catalyzes the synthesis of 7-beta-25-dihydroxycholesterol from 7-oxo-25-hydroxycholesterol in vitro, which acts as a ligand for the G-protein-coupled receptor (GPCR) Epstein-Barr virus-induced gene 2 (EBI2) and may thereby regulate immune cell migration . .

AccessionsP28845
A0A0A0MQV1
X5D2L1
A0A087WU76
ENST00000615289.4
ENST00000367028.6
ENST00000367027.5
ENST00000261465.5