HSCB report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051259Biological processprotein complex oligomerization
GO_0044571Biological process[2Fe-2S] cluster assembly
GO_0060319Biological processprimitive erythrocyte differentiation
GO_0016226Biological processiron-sulfur cluster assembly
GO_0060215Biological processprimitive hemopoiesis
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005739Cellular componentmitochondrion
GO_0051087Molecular functionprotein-folding chaperone binding
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding
GO_0003674Molecular functionmolecular_function
GO_0001671Molecular functionATPase activator activity
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameHSCB
Protein nameHscB mitochondrial iron-sulfur cluster cochaperone (J-type co-chaperone HSC20, isoform CRA_c)
Iron-sulfur cluster co-chaperone protein HscB (DnaJ homolog subfamily C member 20) [Cleaved into: Iron-sulfur cluster co-chaperone protein HscB, cytoplasmic (C-HSC20); Iron-sulfur cluster co-chaperone protein HscB, mitochondrial]
HscB mitochondrial iron-sulfur cluster cochaperone
SynonymsRP3-366L4.2
HSC20
DNAJC20
hCG_40981
DescriptionFUNCTION: [Iron-sulfur cluster co-chaperone protein HscB, mitochondrial]: Acts as a co-chaperone in iron-sulfur cluster assembly in mitochondria . Required for incorporation of iron-sulfur clusters into SDHB, the iron-sulfur protein subunit of succinate dehydrogenase that is involved in complex II of the mitochondrial electron transport chain . Recruited to SDHB by interaction with SDHAF1 which first binds SDHB and then recruits the iron-sulfur transfer complex formed by HSC20, HSPA9 and ISCU through direct binding to HSC20 . Plays an essential role in hematopoiesis (By similarity). .; FUNCTION: [Iron-sulfur cluster co-chaperone protein HscB, cytoplasmic]: Acts as a co-chaperone in iron-sulfur cluster assembly in the cytoplasm . Also mediates complex formation between components of the cytosolic iron-sulfur biogenesis pathway and the CIA targeting complex composed of CIAO1, DIPK1B/FAM69B and MMS19 by binding directly to the scaffold protein ISCU and to CIAO1 . This facilitates iron-sulfur cluster insertion into a number of cytoplasmic and nuclear proteins including POLD1, ELP3, DPYD and PPAT . .

AccessionsENST00000398941.6
ENST00000216027.8
F8WBY7
ENST00000450178.5
B0QYH2
Q8IWL3
ENST00000420442.5