HS3ST6 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of HS3ST6 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of HS3ST6 at tissue level.

III. Associated gene sets

GO_0001835Biological processblastocyst hatching
GO_0015015Biological processheparan sulfate proteoglycan biosynthetic process, enzymatic modification
GO_0000139Cellular componentGolgi membrane
GO_0008467Molecular function[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity

IV. Literature review

[source]
Gene nameHS3ST6
Protein nameHeparan sulfate glucosamine 3-O-sulfotransferase 6 (EC 2.8.2.23) (Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 6) (3-OST-6) (Heparan sulfate 3-O-sulfotransferase 6) (h3-OST-6)
SynonymsHS3ST5
DescriptionFUNCTION: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to heparan sulfate. The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes Simplex Virus-1 (HSV-1) and permits its entry. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate. .

AccessionsENST00000454677.3
Q96QI5
ENST00000293937.5