HORMAD2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of HORMAD2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of HORMAD2 at tissue level.

III. Associated gene sets

GO_0051321Biological processmeiotic cell cycle
GO_0051177Biological processmeiotic sister chromatid cohesion
GO_0005813Cellular componentcentrosome
GO_0005694Cellular componentchromosome
GO_0000795Cellular componentsynaptonemal complex
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameHORMAD2
Protein nameHORMA domain containing 2
HORMA domain-containing protein 2
Synonyms
DescriptionFUNCTION: Essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes. Required for the DNA double-strand break-independent, BRCA1-dependent activation of ATR on the sex chromosomes that is essential for normal sex body formation (By similarity). .

AccessionsF8WES9
ENST00000336726.11
ENST00000450612.5
ENST00000403975.1
Q8N7B1