HORMAD1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of HORMAD1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of HORMAD1 at tissue level.

III. Associated gene sets

GO_0051321Biological processmeiotic cell cycle
GO_0001824Biological processblastocyst development
GO_0007130Biological processsynaptonemal complex assembly
GO_0007283Biological processspermatogenesis
GO_0051598Biological processmeiotic recombination checkpoint signaling
GO_0042138Biological processmeiotic DNA double-strand break formation
GO_0048477Biological processoogenesis
GO_0051177Biological processmeiotic sister chromatid cohesion
GO_0060629Biological processregulation of homologous chromosome segregation
GO_0005694Cellular componentchromosome
GO_0000795Cellular componentsynaptonemal complex
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameHORMAD1
Protein nameHORMA domain-containing protein 1
HORMA domain-containing protein 1 (Cancer/testis antigen 46) (CT46) (Newborn ovary HORMA protein)
SynonymsNOHMA
DescriptionFUNCTION: Plays a key role in meiotic progression. Regulates 3 different functions during meiosis: ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single-stranded DSB ends. Promotes synaptonemal-complex formation independently of its role in homology search. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes. .

AccessionsENST00000368995.8 [Q86X24-4]
ENST00000361824.7 [Q86X24-1]
X6R751
Q86X24
ENST00000322343.11 [Q86X24-2]
X6RG95
ENST00000442853.5
ENST00000368987.5