Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| glutamatergic neuron | 10 studies | 39% ± 27% | |
| GABAergic neuron | 5 studies | 49% ± 21% | |
| astrocyte | 5 studies | 35% ± 15% | |
| neuron | 4 studies | 22% ± 6% | |
| fibroblast | 4 studies | 27% ± 10% | |
| interneuron | 4 studies | 46% ± 25% | |
| GABAergic interneuron | 3 studies | 23% ± 3% | |
| granule cell | 3 studies | 19% ± 0% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 7 studies | 36% ± 22% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 100% | 712.88 | 2633 / 2642 | 69% | 3.79 | 488 / 705 |
| breast | 80% | 128.97 | 368 / 459 | 33% | 1.45 | 366 / 1118 |
| lung | 90% | 194.44 | 523 / 578 | 17% | 0.38 | 195 / 1155 |
| prostate | 76% | 156.22 | 185 / 245 | 17% | 0.36 | 84 / 502 |
| adrenal gland | 26% | 43.06 | 67 / 258 | 66% | 6.16 | 151 / 230 |
| adipose | 81% | 143.01 | 974 / 1204 | 0% | 0 | 0 / 0 |
| bladder | 71% | 101.19 | 15 / 21 | 3% | 0.06 | 13 / 504 |
| pancreas | 34% | 32.87 | 113 / 328 | 38% | 1.52 | 67 / 178 |
| heart | 63% | 85.88 | 545 / 861 | 0% | 0 | 0 / 0 |
| intestine | 60% | 72.88 | 575 / 966 | 2% | 0.08 | 8 / 527 |
| esophagus | 53% | 69.38 | 766 / 1445 | 2% | 0.04 | 4 / 183 |
| kidney | 35% | 36.16 | 31 / 89 | 16% | 0.49 | 144 / 901 |
| thymus | 46% | 47.28 | 301 / 653 | 1% | 0.02 | 7 / 605 |
| uterus | 31% | 31.88 | 53 / 170 | 8% | 0.64 | 37 / 459 |
| ovary | 25% | 32.00 | 45 / 180 | 14% | 0.35 | 61 / 430 |
| muscle | 39% | 36.99 | 312 / 803 | 0% | 0 | 0 / 0 |
| stomach | 27% | 33.16 | 96 / 359 | 1% | 0.02 | 3 / 286 |
| liver | 12% | 10.48 | 26 / 226 | 1% | 0.05 | 3 / 406 |
| blood vessel | 12% | 13.11 | 162 / 1335 | 0% | 0 | 0 / 0 |
| skin | 4% | 3.38 | 67 / 1809 | 1% | 0.02 | 3 / 472 |
| eye | 0% | 0 | 0 / 0 | 1% | 0.03 | 1 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 0 | 0 / 929 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spleen | 0% | 0 | 0 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 45 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0046951 | Biological process | ketone body biosynthetic process |
| GO_0006552 | Biological process | L-leucine catabolic process |
| GO_0005783 | Cellular component | endoplasmic reticulum |
| GO_0005829 | Cellular component | cytosol |
| GO_0048471 | Cellular component | perinuclear region of cytoplasm |
| GO_0016020 | Cellular component | membrane |
| GO_0005789 | Cellular component | endoplasmic reticulum membrane |
| GO_0004419 | Molecular function | hydroxymethylglutaryl-CoA lyase activity |
| GO_0046872 | Molecular function | metal ion binding |
| Gene name | HMGCLL1 |
| Protein name | hydroxymethylglutaryl-CoA lyase (EC 4.1.3.4) 3-hydroxymethyl-3-methylglutaryl-CoA lyase like 1 3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic (EC 4.1.3.4) (3-hydroxy-3-methylglutaryl-CoA lyase-like protein 1) (HMGCL-like 1) (Endoplasmic reticulum 3-hydroxy-3-methylglutaryl-CoA lyase) (er-cHL) |
| Synonyms | hCG_2001183 |
| Description | FUNCTION: Non-mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis, the products of which support energy production in nonhepatic animal tissues. . |
| Accessions | ENST00000515546.2 ENST00000274901.9 [Q8TB92-2] ENST00000370850.6 B7Z4D4 ENST00000428842.1 D6RHJ2 ENST00000370852.6 [Q8TB92-4] Q8TB92 G5E9S9 ENST00000508459.5 ENST00000398661.6 [Q8TB92-1] ENST00000308161.8 [Q8TB92-5] B7Z212 |
